Journal ArticleDOI
Synthetic analogs of the hypothalamic luteinizing hormone releasing factor with increased agonist or antagonist properties.
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This article is published in Biochemistry.The article was published on 1973-11-01. It has received 241 citations till now. The article focuses on the topics: Agonist & Antagonist.read more
Citations
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Book ChapterDOI
Turns in peptides and proteins.
TL;DR: The aim of this chapter is to examine structural and functional roles of turns in peptides and proteins.
Journal ArticleDOI
Gonadotropin-releasing hormone analog design. Structure-function studies toward the development of agonists and antagonists: rationale and perspective.
Marvin J. Karten,Jean Rivier +1 more
TL;DR: The physiological and therapeutic importance attributed to the discovery of the new substance was greatly increased by the prospect of the design of potent and long acting GnRH agonists and antagonists.
Book ChapterDOI
Solid-phase peptide synthesis.
TL;DR: It is a privilege to be able to contribute to this volume in which Professor Zervas’ friends, students, and colleagues have joined together to honor him and his remarkable contributions to peptide chemistry.
Journal ArticleDOI
Molecular Mechanisms of Ligand Interaction with the Gonadotropin-Releasing Hormone Receptor
TL;DR: The structure and Conformation of GnRH and Its Analogs and the roles of individual amino acids in GnRH activity at the mammalian receptor are studied to derive conclusions about peptide structure-activity data.
Journal ArticleDOI
Peptides in the brain: the new endocrinology of the neuron.
TL;DR: After several years of pilot studies involving both biology and relatively simple chemistry in several laboratories in the USA, Europe and Japan, it became clear that characterizing these hypothalamic hypophysiotropic substances would be a challenge of (originally) unsuspected proportions.
References
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Journal ArticleDOI
Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units.
TL;DR: Examples of hydrogen‐bonded, nonhelical conformations which occur in peptides and proteins are discussed—e.g., in cyclohexaglyeyl, an open tetrapeptide Gly‐L‐Pro‐ L‐Leu‐Gly, and in parts of the lysozyme chain.
Journal ArticleDOI
Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence
TL;DR: The complete amino acid sequence of porcine LH- and FSH- releasing hormone has been provisionally determined by the use on a micro-scale of the combined Edman-dansyl procedure coupled with the selective tritiation method for C-terminal analysis.
Journal ArticleDOI
Ferricytochrome c: I. GENERAL FEATURES OF THE HORSE AND BONITO PROTEINS AT 2.8 A RESOLUTION
Richard E. Dickerson,Tsunehiro Takano,David Eisenberg,O.B. Kallai,Lalli Samson,Angela Cooper,Emanuel Margoliash +6 more
TL;DR: The structure of crystalline horse heart ferricytochrome c has been determined by x-ray methods to a resolution of 2.8 A, and the results have been extended to obtain the structure of bonito cy tochrome c as well.
Journal ArticleDOI
Culture of Enzymatically Dispersed Anterior Pituitary Cells: Functional Validation of a Method
TL;DR: The sensitivity of the cultured cells to TRF and LRF is maintained for more than 2 weeks in culture although the magnitude of the secretory response and the intracellular hormone content declines with time in culture.
Related Papers (5)
Gonadotropin-releasing hormone analog design. Structure-function studies toward the development of agonists and antagonists: rationale and perspective.
Marvin J. Karten,Jean Rivier +1 more