Journal ArticleDOI
Taxifolin ameliorates iron overload-induced hepatocellular injury: Modulating PI3K/AKT and p38 MAPK signaling, inflammatory response, and hepatocellular regeneration.
TLDR
Taxifolin inhibited iron-induced apoptosis and enhanced hepatocellular survival as demonstrated by decreased activity of caspase-3 and activation of the pro-survival signaling PI3K/AKT, respectively, and western blotting analysis revealed that taxifolin enhanced liver regeneration as indicated by increased PCNA protein abundance.About:
This article is published in Chemico-Biological Interactions.The article was published on 2020-10-01. It has received 32 citations till now. The article focuses on the topics: Taxifolin & Liver cell.read more
Citations
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Journal ArticleDOI
Dietary Taxifolin Protects Against Dextran Sulfate Sodium-Induced Colitis via NF-κB Signaling, Enhancing Intestinal Barrier and Modulating Gut Microbiota
TL;DR: Taxifolin is a natural antioxidant polyphenol with various bioactivities and has many beneficial effects on human gut health as discussed by the authors, however, little is known of its function on colitis.
Journal ArticleDOI
Dibutyl phthalate-induced oxidative stress, inflammation and apoptosis in grass carp hepatocytes and the therapeutic use of taxifolin.
TL;DR: This study assessed the toxicity of DBP in grass carp hepatocytes and provided a theoretical and research basis for the in vivo study of animal models in the future and showed that TAX alleviates DBP-induced apoptosis in grass carpet hepatocytes through oxidative stress and inflammation, and TAX pretreatment and simultaneous treatment exhibited specific effects.
Journal ArticleDOI
Apple Fermented Products: An Overview of Technology, Properties and Health Effects
TL;DR: In this article, the authors highlighted the advances in the process optimization of apple-based products considering vinegar, cider, pomace, probiotic beverages and spirits' technologies, and illustrated the harmful effects of toxic compounds and strategies to limit their content in cider and apple spirits.
Journal ArticleDOI
Modulating NF-κB, MAPK, and PI3K/AKT signaling by ergothioneine attenuates iron overload-induced hepatocellular injury in rats.
TL;DR: Ergothioneine is a thio-histidine amino acid that has exhibited strong antioxidant and metal chelating activities as discussed by the authors, which has been shown to improve liver cell survival and reduce necrotic cell death.
Journal ArticleDOI
Dihydroquercetin suppresses cigarette smoke induced ferroptosis in the pathogenesis of chronic obstructive pulmonary disease by activating Nrf2-mediated pathway
TL;DR: In this paper , the authors investigated the role of DHQ in the pathogenesis of COPD in vivo and in vitro, and showed that treatment with DHQ significantly reverses the ferroptosis induced by cigarette smoke.
References
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Book ChapterDOI
Microsomal lipid peroxidation.
John A. Buege,Steven D. Aust +1 more
TL;DR: This chapter discusses microsomal lipid peroxidation, a complex process known to occur in both plants and animals that involves the formation and propagation of lipid radicals, the uptake of oxygen, a rearrangement of the double bonds in unsaturated lipids, and the eventual destruction of membrane lipids.
Journal ArticleDOI
Activation and signaling of the p38 MAP kinase pathway
Tyler Zarubin,Jiahuai Han +1 more
TL;DR: The role of p38 as a signal transduction mediator is focused on and the evidence linking p38 to inflammation, cell cycle, cell death, development, cell differentiation, senescence and tumorigenesis in specific cell types is examined.
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Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)
TL;DR: The evidences that NF-kappa B is an oxidative stress-responsive transcription factor of higher eukaryotic cells are discussed, including that antioxidants not only suppress the activation of NF- kappa B by H2O2 but by all other inducers tested so far.
Journal ArticleDOI
Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment.
TL;DR: The role of hepcidin in the pathogenesis of hemochromatosis reveals its similarities to endocrine diseases such as diabetes and indicates new approaches to diagnosis and management of this common disorder in iron metabolism.
Journal ArticleDOI
Molecular biology of Bax and Bak activation and action
TL;DR: How Bax and Bak change conformation and oligomerize, as well as how oligomers might form a pore is reviewed, which indicates that they first form symmetric BH3:groove dimers which can be linked via an interface between the α6-helices to form high order oligomers.