Showing papers in "Journal of Inorganic Biochemistry in 2019"

TL;DR: The human body needs about 20 essential elements in order to function properly and among them, for certain, 10 are metal elements, though for every metal we do need, there is another one in our body we could do without it as discussed by the authors.

TL;DR: Pt(IV) complexes act as prodrugs that are activated inside cancer cells releasing cytotoxic Pt(II) drugs such as cisplatin as well as two axial ligands which have great potential in the attempts to overcome resistance.

TL;DR: It is demonstrated that Tr treatment alleviates Cd-induced liver injury by blocking Nrf2 pathway, restoring autophagy and inhibiting apoptosis, indicating its anti-oxidant action for the whole body.

TL;DR: The emerging need for novel approaches to target the dynamic functional coordination chemistry of the human blood serum albumin in solution, at the atomic level is underlined.

TL;DR: Much work has been carried out on organotin(IV) derivatives with O-donor ligands, however significant fewer reports are found on organotins( IV) with oximes as ligands.

TL;DR: A review of reactions of catalases with their main substrate, hydrogen peroxide, and with oxidizing species such as hydroxyl radical, superoxide, nitric oxide, peroxynitrite, hypochlorous acid, and singlet oxygen is provided.

TL;DR: Melatonin protects against Cr-induced cardiac damage via activating the AMPK/Nrf2 pathway, and shows that MT ameliorated K2Cr2O7-induced oxidative stress, apoptosis, and the release of inflammatory mediators in the rat heart.

TL;DR: The fluorescence spectroscopy revealed that albumin may act as a targeted drug delivery vehicle for Cu(II) complexes, and the most promising compound, from the viewpoint of its NSAID biological activity is 3, due to the presence of the three fluorine atoms participating in the formation of weak hydrogen-bonds at the DNA surface.

TL;DR: The marked variability of the histological liver changes occurring in WD is underlined, and simple steatosis may represent the only pathological changes, frequently associated with glycogenated nuclei.

TL;DR: In this paper, the neuroprotective effects and mechanisms of Lycopene against aluminum chloride (AlCl3)-induced hippocampal lesions were explored, showing that LYC significantly attenuated AlCl3-induced oxidative stress, presenting as the reduced reactive oxygen species, malondialdehyde and 8-hydroxy-2′-deoxyguanosine levels, and increased glutathione level and superoxide dismutase activity.

TL;DR: Strong evidence is presented that the effects of CO in circumventing chemotherapeutic drug resistance is at least in part mediated by the inactivation of endogenous CBS.

TL;DR: Six of the seven complexes were found to be stable in human plasma as well as photostable in acetonitrile upon continuous light irradiation (480 nm) and the determination of the distribution coefficient logP values for the 7 complexes revealed their good water solubility.

TL;DR: Both diseases are caused by defective copper export from distinct cells, and it is a challenge to correct copper dyshomeostasis in either disease though copper depletion in Menkes disease is most challenging.

TL;DR: The antioxidant activity of the ligands and their complexes were determined in vitro by 1,1‑diphenyl‑2‑picrylhydrazyl (DPPH), 2,2'‑azino‑bis(3‑ethylbenzothiazoline‑6‑sulphonic acid (ABTS) and ferric reducing antioxidant power(FRAP), showing that the ligand L1 and L2 and complexes 1 and 2 present significant antioxidant activity.

TL;DR: The pathogenic mechanisms and genetic susceptibilities to metals in PD are explored and strategies for the therapy of PD are focused on, mainly by using chelation therapy to reduce the level of iron.

TL;DR: Interactions of the 3d metal ions Fe2/3+, Cu2+, and Zn2+ with the longest isoform of the human tau protein (htau40) are studied in detail and it is confirmed that these interactions cause structural changes.

TL;DR: Three Pt(II) complexes containing the natural ligands curcumin and caffeine showed moderate to high cytotoxicity and selectivity against several cancer cell lines, while 3 is inactive.

TL;DR: The focus in this review will be on how the chemistry and structural properties of amylin are affected by the interactions between copper, zinc, iron, nickel, gold, ruthenium, and vanadium.

TL;DR: It is worth mentioning that Mn( II) and Zn(II) complexes exhibit interaction modes with highly expressed cancer target proteins under study with higher binding affinity and the results are comparable with reference inhibitors.

TL;DR: All compounds induce caspase-dependent apoptosis in A2780 cells, except [Zn(Sal-Gly)(Bphen)(H2O)], one of the most cytotoxic of the series, indicating that distinct speciation of Zn- and phen-containing species in cell media may affect the cytotoxicity.

TL;DR: The result suggests that Zn(II) complex can be considered as a potential photosensitizer for Photodynamic therapy (PDT), and the spectroscopic properties, photogeneration of singlet oxygen (1O2), and cytotoxicity of these complexes have been investigated.

TL;DR: The results demonstrate that CuLA inhibits cancer cells through dual pathways involving DNA damage and mitochondrial dysfunction, and the introduction of aspirin not only enhances the antitumour efficacy but also reduces the inflammatory threat.

TL;DR: The X-ray crystal structure of PV14 was solved and it is suggested that PV14 exibited a high potential to act as an in vivo inhibitor of the Na+/K+-ATPase associated with chloride secretion.

TL;DR: The interaction of the complexes with bovine (BSA) and human (HSA) serum albumin proteins was studied by fluorescence emission spectroscopy and the relatively high binding constants revealed the reversible binding of the Complex 1-4 to the albumins.

TL;DR: Although only [Cu(His)2Cl2] showed a good neurocompatibility, the cytotoxicity of the other copper complexes was lower compared to equivalent concentrations of CuCl2, and study of these complexes may help to improve chelation therapy for copper dysfunctions.

TL;DR: The solution thermodynamics of complexes formed between Zr(IV) and this hexadentate chelating agent is presented, overcoming all the difficulties with the characterisation of the aqueous solution chemistry of Zr (IV) complexes, like strong hydrolysis and lack of spectral information.

TL;DR: Challenges and opportunities to increase the translational potential of these antibody drug conjugates based on metal-containing cytotoxic payloads will be discussed.

TL;DR: This review focuses on NAD(P)H cofactor regeneration catalyzed by transition metal complexes such as rhodium, ruthenium and iridium complexes using cheap reducing agents such as hydrogen (H2) and ethanol, which have attracted increasing attention as sustainable energy carriers.

TL;DR: Three Ru(II) complexes with salicylate as ligand were synthesized and characterized and the anticancer effect exerted by them was evaluated, found to exhibit obvious anticancer activity, in comparison with cisplatin, against cancer cell lines, while displaying low toxicity to the normal cell line BEAS-2B.

TL;DR: The appendage of additional metal binding ligands on the imidazole nucleobase appears to be a valid approach to improve the biochemical properties of modified triphosphates in the context of an expansion of the genetic alphabet with metal base pairs.