Journal ArticleDOI
Temperature- and pH-Responsive Dense Copolymer Brushes Prepared by ATRP
TLDR
In this article, the lower critical solution temperature (LCST) of MEO2MA-stat-MAA decreased with the increasing molar fraction of MAA in the copolymer in deionized water but increased in buffer solution at pH 7.Abstract:
Dual responsive molecular brushes consisting of statistical copolymers of di(ethylene glycol) methyl ether methacrylate (MEO2MA) and either methacrylic acid (MAA) or N,N-dimethylaminoethyl methacrylate (DMAEMA) were synthesized by grafting from poly(2-(2-bromoisobutyroyloxy)ethyl methacrylate (PBIEM) macroinitiators using atom transfer radical polymerization (ATRP). Copolymer brushes with controlled composition and molecular weights ranging from Mn = 600 000 to 1 400 000 with polydispersity indexes (Mw/Mn) between 1.18 and 1.45 were obtained. The lower critical solution temperature (LCST) of MEO2MA-stat-MAA decreased with the increasing molar fraction of MAA in the copolymer in deionized water but increased in buffer solution at pH 7. At pH 9, the hydrophilicity of polymer increased with ionization of carboxylic acid to further raise the LCST. On the other hand, the LCST of MEO2MA-stat-DMAEMA copolymers increased with increasing DMAEMA content at pH 4, 7, and 9. A bottle-brush terpolymer prepared from all...read more
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Stimuli-responsive molecular brushes
TL;DR: In this paper, the authors review the general aspects of molecular brushes and polymeric responsive systems and highlight the rational approaches to induce stimuli-responsiveness in molecular brush systems, which are unique for molecular brushes since these conformational changes can be restricted to a single molecule.
Journal ArticleDOI
ATRP in the design of functional materials for biomedical applications
TL;DR: Recent advances in the preparation of polymer-based nanomaterials using ATRP are reviewed, including polymer bioconjugates, block copolymer-based drug delivery systems, cross-linked microgels/nanogels, diagnostic and imaging platforms, tissue engineering hydrogels, and degradable polymers.
Journal ArticleDOI
Temperature responsive bio-compatible polymers based on poly(ethylene oxide) and poly(2-oxazoline)s
TL;DR: In this article, a review of the thermodynamic properties of two important polymer classes in aqueous solution, namely poly(2-oxazoline)s and poly(ethylene oxide)s, is presented.
Journal ArticleDOI
Copper-Mediated Living Radical Polymerization (Atom Transfer Radical Polymerization and Copper(0) Mediated Polymerization): From Fundamentals to Bioapplications
Cyrille Boyer,Nathaniel Corrigan,Kenward Jung,Diep Nguyen,Thuy-Khanh Nguyen,Nik Nik M. Adnan,Susan Oliver,Sivaprakash Shanmugam,Jonathan Yeow +8 more
TL;DR: Radical Polymerization and Copper(0) Mediated polymerization): From Fundamentals to Bioapplications
Journal ArticleDOI
Thermo-Induced Self-Assembly of Responsive Poly(DMAEMA‑b‑DEGMA) Block Copolymers into Multi- and Unilamellar Vesicles
Christian Pietsch,Ulrich Mansfeld,Carlos Guerrero-Sanchez,Stephanie Hoeppener,Antje Vollrath,Michael Wagner,Richard Hoogenboom,Simon Saubern,San H. Thang,C. Remzi Becer,John Chiefari,Ulrich S. Schubert +11 more
TL;DR: In this article, a series of thermoresponsive diblock copolymers of poly[2-(dimethylamino)ethyl methacrylate-block-di(ethyleneglycol) methyl ether methacyl], poly(DMAEMA-b-DEGMA), were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerizations.
References
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Journal ArticleDOI
Controlled/"living" radical polymerization. atom transfer radical polymerization in the presence of transition-metal complexes
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The dawning era of polymer therapeutics
TL;DR: The successful clinical application of polymer–protein conjugates, and promising clinical results arising from trials with polymer–anticancer-drug conjugate, bode well for the future design and development of the ever more sophisticated bio-nanotechnologies that are needed to realize the full potential of the post-genomic age.