Journal ArticleDOI
The activity of class I, II, III, and IV of alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase in pancreatic cancer.
TLDR
Pancreatic cancer tissue exhibits higher activity of class III ADH isoenzyme than healthy tissue, and it is considered that oxidative pathway of ethanol metabolism via ADH and ALDH does not play a role in pancreatic carcinogenesis.Abstract:
Objectives:The pancreas can metabolize ethanol via oxidative pathway involving the enzymes alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) as well as the nonoxidative pathway. In this study, we compared the activity of ADH isoenzymes and ALDH in the pancreatic cancer with the activityread more
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Tumorigenic and metastatic activity of human thyroid cancer stem cells.
Matilde Todaro,Flora Iovino,Vincenzo Eterno,Patrizia Cammareri,Guido Gambara,Virginia Espina,Gaspare Gulotta,Francesco Dieli,Silvia Giordano,Ruggero De Maria,Giorgio Stassi +10 more
TL;DR: The identification of tumorigenic and metastagenic thyroid cancer cells may provide unprecedented preclinical tools for development and preclinical validation of novel targeted therapies.
Journal ArticleDOI
Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in the cancer diseases
TL;DR: Significant differences of ADH isoenzymes activities between cancer tissues and healthy organs may be a factor intensifying carcinogenesis by the increased ability to acetaldehyde formation from ethanol and disorders in metabolism of some biologically important substances.
Journal ArticleDOI
Moving Forward in Human Mammary Stem Cell Biology and Breast Cancer Prognostication Using ALDH1
TL;DR: It is elegantly demonstrated that aldehyde dehydrogenase 1 (ALDH1) facilitates the identification and isolation of normal and malignant human mammary stem cells in vitro, in vivo, and in situ in fixed tissues.
Journal ArticleDOI
An experimental analysis of acquired impulse control among adult humans intolerant to alcohol
TL;DR: It is found that alcohol intolerance, which occurs randomly and leads affected people systematically to resist the impulse to consume alcohol, enables improved impulse control in another behavioral domain and indicates that impulse control can be developed in adult populations as a result of self-control behaviors in natural environments.
Journal ArticleDOI
Multiple Pluripotent Stem Cell Markers in Human Anaplastic Thyroid Cancer: The Putative Upstream Role of SOX2
Valeria Carina,Giovanni Zito,Giuseppe Pizzolanti,Pierina Richiusa,Angela Criscimanna,Vito Rodolico,Laura Tomasello,Maria Pitrone,Walter Arancio,Carla Giordano +9 more
TL;DR: The data demonstrate that SOX2 switch-off through ABCG2 transporter down-regulation has a major role in overcoming CSC chemotherapy resistance and might be useful in identifying cells with a stem-like phenotype capable of resisting conventional chemotherapy.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
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Journal ArticleDOI
Pancreatitis and the risk of pancreatic cancer.
Journal ArticleDOI
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Buckminster Farrow,B. Mark Evers +1 more
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Journal ArticleDOI
Evidence for the identity of glutathione-dependent formaldehyde dehydrogenase and class III alcohol dehydrogenase.
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Journal ArticleDOI
Pancreatitis is a risk factor for pancreatic cancer
Pradeep Bansal,Amnon Sonnenberg +1 more
TL;DR: The increase of the risk with decreasing time before the diagnosis of cancer may indicate that a fraction of pancreatic cancers are initially misdiagnosed as pancreatitis, and a history of pancreatitis constitutes a significant risk for subsequent development of pancreating cancer.