Journal ArticleDOI
The AP-1 site and MMP gene regulation: what is all the fuss about?
TLDR
There is an essential interaction with other cis-acting sequences in the promoters and with certain transcription factors that bind to these sequences that control the transcription of the MMPs in response to particular inducers and repressors.About:
This article is published in Matrix Biology.The article was published on 1997-03-01. It has received 508 citations till now. The article focuses on the topics: Promoter & General transcription factor.read more
Citations
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Journal ArticleDOI
Regulation of matrix metalloproteinase expression in tumor invasion
TL;DR: The role of mitogen‐activated protein kinases and AP‐1 and ETS transcription factors in the regulation of MMP gene expression during invasion process is focused on.
Journal ArticleDOI
RHO-GTPases and cancer.
TL;DR: The RAS oncogenes are members of a large family of small GTPases that bind GTP and hydrolyse it to GDP and the switching between these two states regulates a wide range of cellular processes.
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Regulation of matrix metalloproteinases: an overview.
TL;DR: The recent view about the role of stromal cells in the progression of cancer cell growth and metastasis is particularly interesting, and additional studies about the regulation of MMP gene expression and activity in malignancies are needed to understand the role and regulation ofMMPs in tumor cell invasion.
Journal ArticleDOI
Matrix metalloproteinases: a tail of a frog that became a prince
TL;DR: It is 40 years since the first member of what came to be known as the matrix metalloproteinase (MMP) family was described and structural, molecular and biochemical approaches have subsequently contributed to piecing together the puzzle of how MMPs work, and how they contribute to various disease processes.
Journal ArticleDOI
Myocardial Matrix Remodeling and the Matrix Metalloproteinases: Influence on Cardiac Form and Function
TL;DR: The purpose of this review is to examine and redefine the myocardial matrix as a critical and dynamic entity with respect to the remodeling process encountered with MI, hypertension, or cardiomyopathic disease, and to dispel the historical belief that the myCardial matrix is a passive structure.
References
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Journal ArticleDOI
Matrix metalloproteinases and their inhibitors in connective tissue remodeling.
TL;DR: Latency is overcome by physical, chemical, and enzymatic treatments that separate the cysteine residue from the zinc Expression of the metalloproteinases is switched on by a variety of agents acting through regulatory elements of the gene, particularly the AP‐1 binding site.
Journal ArticleDOI
Matrix Metalloproteinases: A Review
Henning Birkedal-Hansen,William G. I. Moore,M.K. Bodden,L.J. Windsor,B. Birkedal-Hansen,Arthur A. Decarlo,Jeffrey A. Engler +6 more
TL;DR: The present review discusses in detail the primary structures and the overlapping yet distinct substrate specificities of MMPs as well as the mode of activation of the unique MMP precursors.
Journal ArticleDOI
Metalloproteinases and their inhibitors in matrix remodeling.
TL;DR: Experiments designed to improve the understanding of metalloproteinase regulation have also resulted in new insights into mechanisms by which growth factors and proto-oncogenes may regulate biological processes.
Journal ArticleDOI
Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone
Carsten Jonat,Hans J. Rahmsdorf,Kun-Koo Park,Andrew C.B. Cato,Stephan Gebel,Helmut Ponta,Peter Herrlich +6 more
TL;DR: Coprecipitation experiments suggest direct AP-1-hormone receptor interaction, which also possibly explains the reverse experiment: overexpression of Fos or Jun inhibits the expression of hormone-dependent genes.
Book
The Retinoids : biology, chemistry, and medicine
TL;DR: Retinoids In Photosensitive Systems John C. Saari Introduction / Overview of the Visual Process / Chromophores of Visual Pigments /photoisomerisation / Wavelength Regulation The Visual Cycle /Cellular Uptake of Retinol.
Related Papers (5)
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.
Peter Angel,Michael Karin +1 more