Journal ArticleDOI
The basal forebrain-cortical cholinergic system: interpreting the functional consequences of excitotoxic lesions
TLDR
It is proposed that many of the functional consequences of ibotenic acid lesions on mnemonic tasks cannot be attributed to disruption of basal forebrain cholinergic systems, but may instead result from damage in the globus pallidus to corticostriatal output pathways.About:
This article is published in Trends in Neurosciences.The article was published on 1991-11-01. It has received 488 citations till now. The article focuses on the topics: Cholinergic neuron & Basal forebrain.read more
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The cholinergic hypothesis of Alzheimer’s disease: a review of progress
TL;DR: The existing scientific applicability of the original cholinergic hypothesis of Alzheimer’s disease is examined by describing the biochemical and histopathological changes of neurotransmitter markers that occur in the brains of patients with Alzheimer's disease both at postmortem and neurosurgical cerebral biopsy and the behavioural consequences of cholinomimetic drugs andCholinergic lesions.
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Central cholinergic systems and cognition
TL;DR: Evidence is presented that the nucleus basalis-neocortical cholinergic system contributes greatly to visual attentional function, but not to mnemonic processes per se, and it is suggested that nucleus basali-amygdala cholinerential projections have a role in the retention of affective conditioning while brainstem cholinery projections to the thalamus and midbrain dopamine neurons affect basic arousal processes.
Journal Article
The cholinergic hypothesis of alzheimer's disease : a review of progress. authors' reply
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Alzheimer's disease: Targeting the Cholinergic System
Talita H. Ferreira-Vieira,Isabella M. Guimaraes,Flavia Rodrigues da Silva,Fabiola M. Ribeiro +3 more
TL;DR: Synthesis of cholinergic neurons located in the basal forebrain, including the neurons that form the nucleus basalis of Meynert, are severely lost in Alzheimer’s disease, and drugs that act on the choline system represent a promising option to treat AD patients.
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The nucleus accumbens as a complex of functionally distinct neuronal ensembles : an integration of behavioural, electrophysiological and anatomical data
TL;DR: This dissertation aims to provide a history of web exceptionalism from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including the year in which descriptions of “Web 2.0” began to circulate.
References
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Place navigation impaired in rats with hippocampal lesions.
TL;DR: It is reported that, in addition to a spatial discrimination impairment, total hippocampal lesions also cause a profound and lasting placenavigational impairment that can be dissociated from correlated motor, motivational and reinforcement aspects of the procedure.
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The Cholinergic Hypothesis of Geriatric Memory Dysfunction
Raymond T. Bartus,Raymond T. Bartus,Reginald L. Dean,Bernard Beer,Bernard Beer,Arnold S. Lippa,Arnold S. Lippa +6 more
TL;DR: Biochemical, electrophysiological, and pharmacological evidence supporting a role for cholinergic dysfunction in age-related memory disturbances is critically reviewed and an attempt has been made to identify pseudoissues, resolve certain controversies, and clarify misconceptions that have occurred in the literature.
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Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain.
Peter J. Whitehouse,Donald L. Price,Robert G. Struble,Arthur W. Clark,Joseph T. Coyle,Mahlon R. DeLong +5 more
TL;DR: Demonstration of selective degeneration of neurons of the nucleus basalis of Meynert represents the first documentation of a loss of a transmitter-specific neuronal population in a major disorder of higher cortical function and points to a critical subcortical lesion in Alzheimer's patients.
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Alzheimer's disease: a disorder of cortical cholinergic innervation
TL;DR: Advances in neurotransmitter systems involved in the symptomatic manifestations of neurological and psychiatric disorders reflect a close interaction between experimental and clinical neuroscientists in which information derived from basic neurobiology is rapidly utilized to analyze disorders of the human brain.