Journal ArticleDOI
The Biochemistry of Memory: A New and Specific Hypothesis.
Gary Lynch,Michael Baudry +1 more
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TLDR
A synaptic process with properties required for an intermediate step in memory storage is uncovered and hypothesized to be responsible for those forms of memory localized in the telencephalon.Abstract:
Recent studies have uncovered a synaptic process with properties required for an intermediate step in memory storage. Calcium rapidly and irreversibly increases the number of receptors for glutamate (a probable neurotransmitter) in forebrain synaptic membranes by activating a proteinase (calpain) that degrades fodrin, a spectrin-like protein. This process provides a means through which physiological activity could produce long-lasting changes in synaptic chemistry and ultrastructure. Since the process is only poorly represented in the brain stem, it is hypothesized to be responsible for those forms of memory localized in the telencephalon.read more
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Selective impairment of learning and blockade of long-term potentiation by an N -methyl-D-aspartate receptor antagonist, AP5
TL;DR: This article showed that chronic intraventricular infusion of D,L-AP5 causes a selective impairment of place learning, which is highly sensitive to hippocampal damage, without affecting visual discrimination learning.
Journal ArticleDOI
Long-Term Potentiation--A Decade of Progress?
TL;DR: A simple model is described that unifies much of the data that previously were viewed as contradictory about the molecular mechanisms of this long-lasting increase in synaptic strength in the hippocampus.
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Synaptic plasticity and memory: an evaluation of the hypothesis
TL;DR: It is concluded that a wealth of data support the notion that synaptic plasticity is necessary for learning and memory, but that little data currently supports the notion of sufficiency.
Journal ArticleDOI
AMPA Receptor Trafficking and Synaptic Plasticity
TL;DR: The growing literature that supports a critical role for AMPA receptors trafficking in LTP and LTD is reviewed, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins.
Glutamate and pathophysiology of hypoxic-ischemic brain damage
S M Rothman,J W Olney +1 more
TL;DR: It is suggested that glutamate plays a key role in ischemic brain damage, and that drugs which decrease the accumulation of glutamate or block its postsynaptic effects may be a rational therapy for stroke.
References
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Journal ArticleDOI
Loss of recent memory after bilateral hippocampal lesions.
TL;DR: The results of these studies point to the importance of the hippocampal complex for normal memory function in patients who had undergone similar, but less radical, bilateral medial temporallobe resections, and as a warning to others of the risk to memory involved in bilateral surgical lesions of the hippocampusal region.
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Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
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Preserved learning and retention of pattern-analyzing skill in amnesia: dissociation of knowing how and knowing that
TL;DR: The results indicate that the class of preserved learning skills in amnesia is broader than previously reported and support the hypothesis that such a distinction is honored by the nervous system.
Journal ArticleDOI
Hippocampus, space, and memory
TL;DR: It is proposed that the hippocampus is selectively involved in behaviors that require working memory, irrespective of the type of material (spatial or nonspatial) that is to be processed by that memory.
Journal ArticleDOI
Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat.
TL;DR: The amount of synaptic enhancement was statistically correlated with the ability to perform the circular platform task both within and between groups, and the aftereffects of the high-frequency stimulation selectively impaired the old rats' spontaneous alternation behavior on a T-maze.
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Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more