The cerebellum after trauma: Resting‐state functional connectivity of the cerebellum in posttraumatic stress disorder and its dissociative subtype
Daniela Rabellino,Maria Densmore,Maria Densmore,Jean Théberge,Jean Théberge,Margaret C. McKinnon,Ruth A. Lanius,Ruth A. Lanius +7 more
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In this paper, the authors compared seed-based resting-state functional connectivity of the anterior cerebellum and anterior vermis with brain regions involved in somatosensory processing, multisensory integration, and bodily self-consciousness.Abstract:
The cerebellum plays a key role not only in motor function but also in affect and cognition. Although several psychopathological disorders have been associated with overall cerebellar dysfunction, it remains unclear whether different regions of the cerebellum contribute uniquely to psychopathology. Accordingly, we compared seed-based resting-state functional connectivity of the anterior cerebellum (lobule IV-V), of the posterior cerebellum (Crus I), and of the anterior vermis across posttraumatic stress disorder (PTSD; n = 65), its dissociative subtype (PTSD + DS; n = 37), and non-trauma-exposed healthy controls (HC; n = 47). Here, we observed decreased functional connectivity of the anterior cerebellum and anterior vermis with brain regions involved in somatosensory processing, multisensory integration, and bodily self-consciousness (temporo-parietal junction, postcentral gyrus, and superior parietal lobule) in PTSD + DS as compared to PTSD and HC. Moreover, the PTSD + DS group showed increased functional connectivity of the posterior cerebellum with cortical areas related to emotion regulation (ventromedial prefrontal and orbito-frontal cortex, subgenual anterior cingulum) as compared to PTSD. By contrast, PTSD showed increased functional connectivity of the anterior cerebellum with cortical areas associated with visual processing (fusiform gyrus), interoceptive awareness (posterior insula), memory retrieval, and contextual processing (hippocampus) as compared to HC. Finally, we observed decreased functional connectivity between the posterior cerebellum and prefrontal regions involved in emotion regulation, in PTSD as compared to HC. These findings not only highlight the crucial role of each cerebellar region examined in the psychopathology of PTSD but also reveal unique alterations in functional connectivity distinguishing the dissociative subtype of PTSD versus PTSD.read more
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Self-Rated versus Clinician-Rated Assessment of Posttraumatic Stress Disorder: An Evaluation of Diagnostic Discrepancies between the PTSD Checklist for DSM-5 (PCL-5) and the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5)
TL;DR: This paper presents a meta-analyses of the determinants of infectious disease and its mechanisms and aims are to establish a chronology of disease progression and describe the immune responses of mice to these diseases.
Journal ArticleDOI
Classifying heterogeneous presentations of PTSD via the default mode, central executive, and salience networks with machine learning
Andrew A. Nicholson,Andrew A. Nicholson,Sherain Harricharan,Maria Densmore,Richard W. J. Neufeld,Tomas Ros,Margaret C. McKinnon,Paul A. Frewen,Jean Théberge,Rakesh Jetly,David Pedlar,Ruth A. Lanius +11 more
TL;DR: A comparison of ICNs between PTSD, dissociative subtype PTSD, and healthy controls revealed unique group connectivity to brain areas associated with PTSD symptoms.
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Cerebellar and Prefrontal Cortical Alterations in PTSD: Structural and Functional Evidence:
Sophie E. Holmes,Dustin Scheinost,Nicole DellaGioia,Margaret T. Davis,David Matuskey,Robert H. Pietrzak,Robert H. Pietrzak,Michelle Hampson,John H. Krystal,John H. Krystal,Irina Esterlis,Irina Esterlis +11 more
TL;DR: Structural and functional alterations in PTSD converging on the PFC and cerebellum are demonstrated, adding to a growing evidence base implicating cerebellar involvement in the pathophysiology of PTSD.
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The cerebellum under stress
TL;DR: A hypothesis for cerebellar function in stressful conditions is proposed, relating it to stress-induced psychopathologies, to provide a clearer picture of stress-related neural circuitry and stimulate cerebellum-stress research, which might contribute to the development of improved treatment strategies for stress- related disorders.
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Amygdala functional connectivity in the acute aftermath of trauma prospectively predicts severity of posttraumatic stress symptoms.
Emily L. Belleau,Emily L. Belleau,Lauren E. Ehret,Jessica L. Hanson,Karen J. Brasel,Christine L. Larson,Terri A. deRoon-Cassini +6 more
TL;DR: Results extend cross-sectional studies implicating abnormal FC of the amygdala with other brain regions involved in somatosensory processing, motor control, and emotional information processing in PTSD, to the prospective prediction of risk for chronic PTSD.
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