Journal ArticleDOI
The Chemistry and Biology of Alkannin, Shikonin, and Related Naphthazarin Natural Products.
Vassilios P. Papageorgiou,Andreana N. Assimopoulou,Elias A. Couladouros,David Hepworth,Kyriacos C. Nicolaou +4 more
TLDR
Wound healing properties of plant extracts that contain the naphthoquinone natural products alkannin and shikonin have been known for many centuries and their production both by cell cultures and chemical synthesis has been studied extensively.Citations
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Journal ArticleDOI
Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2
Junru Chen,Junru Chen,J Xie,J Xie,Zhi Jiang,Baohong Wang,Baohong Wang,Yungui Wang,Xinyang Hu,Xinyang Hu +9 more
TL;DR: As PKM2 universally expresses in cancer cells and dictates the last rate-limiting step of glycolysis vital for cancer cell proliferation and survival, enantiomeric shikonin and alkannin may have potential in future clinical application.
Journal ArticleDOI
Modulating ROS to overcome multidrug resistance in cancer.
Qingbin Cui,Jing-Quan Wang,Yehuda G. Assaraf,Liang Ren,Pranav Gupta,Liuya Wei,Charles R. Ashby,Dong-Hua Yang,Zhe-Sheng Chen +8 more
TL;DR: The critical and targetable redox-regulating enzymes, including mitochondrial electron transport chain complexes, NADPH oxidases (NOXs), enzymes related to glutathione metabolism, glutamate/cystine antiporter xCT, thioredoxin reductases (TrxRs), nuclear factor erythroid 2-related factor 2 (Nrf2), and their roles in regulating cellular ROS levels, drug resistance as well as their clinical significance are discussed.
Journal ArticleDOI
Cellular pharmacology studies of shikonin derivatives.
TL;DR: It is hypothesized that shikonin is an effective inhibitor of protein–protein interaction with multiple targets in both the intracellular and extracellular compartments, which can account for the broad spectrum of shik onin biological and pharmacological activities.
Journal ArticleDOI
The activity of Arabidopsis glycosyltransferases toward salicylic acid, 4-hydroxybenzoic acid, and other benzoates.
Eng-Kiat Lim,Doucet Charlotte Juliette,Yi Li,Luisa Elias,Dawn Worrall,Steven P. Spencer,Joe Ross,Dianna J. Bowles +7 more
TL;DR: New tools for biotransformation reactions in vitro and a basis for engineering benzoate metabolism in plants are provided.
Journal ArticleDOI
Understanding cancer and the anticancer activities of naphthoquinones – a review
TL;DR: The most recent applications of naphthoquinones and their derivatives in cancer drug discovery are described and the biology relevant to the design of novel naphTHoquinone anticancer agents is discussed to contribute to understanding cancer.
References
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Book
Herbal Drugs and Phytopharmaceuticals: A Handbook for Practice on a Scientific Basis
TL;DR: This new edition of Herbal Drugs and Phytopharmaceuticals takes the advances made in medicinal plants research and phytotherapy into account and offers reliable, highly pertinent information.
Book
Chemical aspects of biosynthesis
TL;DR: The shikimic acid pathway: biosynthesis of phenols, lignans, flavonoids, and alkaloids Ecological chemistry as discussed by the authors, is a pathway for the synthesis of polyketides.