Journal ArticleDOI
The chemistry and biology of left-handed z-dna
TLDR
Z-DNA in Other Naturally Occurring Sequences, e.g. d(CA/GT}n, Drosophilia and Chironomus, and Other Species : 831.Abstract:
CONTENTS PERSPECTIVE AND SUMMARY 792 INTRODUCTION 793 MOLECULAR STRUCTURE OF Z-DNA 795 METHODS FOR DETECTING Z-ONA 803 Physical-Chemical Methods 804 Use of Specific Anti-Z-DN A Antibodies 806 PHYSICAL-CHEMICAL STUDIES OF Z-DNA 809 Ultraviolet Circular Dichroism and Absorbance 809 Raman Spectra 810 Nuclear Magnetic Resonance Studies 8 1 1 Other Methods 813 Theoretical Analyses: Energetics and Mechanics 813 CHEMICAL FACTORS INFLUENCING THE EQUILIBRIUM BETWEEN BAND Z-DNA 816 Covalent DN A Modifications 816 Ions, Solvents, and Small Molecules 818 Cytosine Methylation in CG Sequences Stabilizes Z-DNA 819 NEGATIVE SUPERCOILING STABILIZES Z-DNA 821 Topological Constraints in DN A 821 Form V DNA 825 PROTEINS THAT BIND TO Z-DNA 826 NUCLEOTIDE SEQUENCES THAT FAVOR Z-DNA FORMATION 828 Polymers and Repetitive Sequences, e.g. d(CA/GT}n 828 Z-DNA in Other Naturally Occurring Sequences 829 CYTOLOGICAL STUDIES OF Z -DNA IN CHROMOSOMES 830 Drosophilia and Chironomus 830 Other Species : 831read more
Citations
More filters
Journal ArticleDOI
A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.
Robert K. Moyzis,Judy M. Buckingham,L. S. Cram,M. Dani,Larry L. Deaven,M. D. Jones,J. Meyne,Robert L. Ratliff,Jung-Rung Wu +8 more
TL;DR: A highly conserved repetitive DNA sequence, (TTAGGG)n, has been isolated from a human recombinant repetitive DNA library and its similarity to functional telomeres isolated from lower eukaryotes suggest that this sequence is a functional human telomere.
Journal ArticleDOI
Steroid Receptor Regulated Transcription of Specific Genes and Gene Networks
TL;DR: Information is provided on how to identify the Steroid Receptors, Receptor Binding Sites, and other mechanisms that aid in the identification of the receptors and their locations in the genome.
Journal ArticleDOI
Identification of a chromosome 18q gene that is altered in colorectal cancers
Eric R. Fearon,Kathleen R. Cho,Janice M. Nigro,Scott E. Kern,Jonathan W. Simons,J. Michael Ruppert,Stanley R. Hamilton,Antonette C. Preisinger,Giles Thomas,Kenneth W. Kinzler,Bert Vogelstein +10 more
TL;DR: A contiguous stretch of DNA comprising 370 kilobase pairs has now been cloned from a region of chromosome 18q suspected to reside near the DCC gene, which may play a role in the pathogenesis of human colorectal neoplasia, perhaps through alteration of the normal cell-cell interactions controlling growth.
Journal ArticleDOI
Nanomaterials based on DNA.
TL;DR: This work has shown that it is possible to construct novel DNA-based materials by combining these features in a self-assembly protocol by constructing polyhedrons, whose edges consist of double helical DNA and whose vertices correspond to the branch points.
Book
DNA Structure and Function
TL;DR: This chapter discusses the structure and function of DNA, which is a right handed helix of two individual antiparallel DNA strands that is the source of all intrinsic genetic information.
References
More filters
Journal ArticleDOI
The Raman spectra of left-handed DNA oligomers incorporating adenine-thymine base pairs
J.M. Benevides,Andrew H.-J. Wang,G. A. Van Der Marel,J. H. Van Boom,Alexander Rich,G.J. Thomas +5 more
TL;DR: Results show that the 670cm-1 line of syn G is highly sensitive to the change from C3'-endo to C2'-endo pucker, and the 1200-1500 cm-1 region of the Raman spectrum of the A-T double helix is greatly altered by the B-to-Z transition.
Related Papers (5)
Salt-induced co-operative conformational change of a synthetic DNA: Equilibrium and kinetic studies with poly(dG-dC)☆
Fritz M. Pohl,Thomas M. Jovin +1 more
Effects of methylation on a synthetic polynucleotide: the B--Z transition in poly(dG-m5dC).poly(dG-m5dC).
Michael J. Behe,Gary Felsenfeld +1 more