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Journal ArticleDOI

The chemistry and biology of left-handed z-dna

Alexander Rich, +2 more
- 01 Jan 1984 - 
- Vol. 53, Iss: 1, pp 791-846
TLDR
Z-DNA in Other Naturally Occurring Sequences, e.g. d(CA/GT}n, Drosophilia and Chironomus, and Other Species : 831.
Abstract
CONTENTS PERSPECTIVE AND SUMMARY 792 INTRODUCTION 793 MOLECULAR STRUCTURE OF Z-DNA 795 METHODS FOR DETECTING Z-ONA 803 Physical-Chemical Methods 804 Use of Specific Anti-Z-DN A Antibodies 806 PHYSICAL-CHEMICAL STUDIES OF Z-DNA 809 Ultraviolet Circular Dichroism and Absorbance 809 Raman Spectra 810 Nuclear Magnetic Resonance Studies 8 1 1 Other Methods 813 Theoretical Analyses: Energetics and Mechanics 813 CHEMICAL FACTORS INFLUENCING THE EQUILIBRIUM BETWEEN BAND Z-DNA 816 Covalent DN A Modifications 816 Ions, Solvents, and Small Molecules 818 Cytosine Methylation in CG Sequences Stabilizes Z-DNA 819 NEGATIVE SUPERCOILING STABILIZES Z-DNA 821 Topological Constraints in DN A 821 Form V DNA 825 PROTEINS THAT BIND TO Z-DNA 826 NUCLEOTIDE SEQUENCES THAT FAVOR Z-DNA FORMATION 828 Polymers and Repetitive Sequences, e.g. d(CA/GT}n 828 Z-DNA in Other Naturally Occurring Sequences 829 CYTOLOGICAL STUDIES OF Z -DNA IN CHROMOSOMES 830 Drosophilia and Chironomus 830 Other Species : 831

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Citations
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A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.

TL;DR: A highly conserved repetitive DNA sequence, (TTAGGG)n, has been isolated from a human recombinant repetitive DNA library and its similarity to functional telomeres isolated from lower eukaryotes suggest that this sequence is a functional human telomere.
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Steroid Receptor Regulated Transcription of Specific Genes and Gene Networks

TL;DR: Information is provided on how to identify the Steroid Receptors, Receptor Binding Sites, and other mechanisms that aid in the identification of the receptors and their locations in the genome.
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Identification of a chromosome 18q gene that is altered in colorectal cancers

TL;DR: A contiguous stretch of DNA comprising 370 kilobase pairs has now been cloned from a region of chromosome 18q suspected to reside near the DCC gene, which may play a role in the pathogenesis of human colorectal neoplasia, perhaps through alteration of the normal cell-cell interactions controlling growth.
Journal ArticleDOI

Nanomaterials based on DNA.

TL;DR: This work has shown that it is possible to construct novel DNA-based materials by combining these features in a self-assembly protocol by constructing polyhedrons, whose edges consist of double helical DNA and whose vertices correspond to the branch points.
Book

DNA Structure and Function

TL;DR: This chapter discusses the structure and function of DNA, which is a right handed helix of two individual antiparallel DNA strands that is the source of all intrinsic genetic information.
References
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Journal ArticleDOI

The Raman spectra of left-handed DNA oligomers incorporating adenine-thymine base pairs

TL;DR: Results show that the 670cm-1 line of syn G is highly sensitive to the change from C3'-endo to C2'-endo pucker, and the 1200-1500 cm-1 region of the Raman spectrum of the A-T double helix is greatly altered by the B-to-Z transition.
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