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Journal ArticleDOI

The circadian basis of mood disorders: Recent developments and treatment implications

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TLDR
Evidence is emerging that a disruption of the normal circadian rhythmicity occurs at least in a subgroup of depressed patients and that interventions able to resynchronize the human circadian system, including sleep deprivation, light therapy and drugs specifically acting on the endogenous clock system, have proven antidepressant effects.
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This article is published in European Neuropsychopharmacology.The article was published on 2008-10-01. It has received 172 citations till now. The article focuses on the topics: Circadian clock & Dark therapy.

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Citations
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The Effect of Exercise Training on Anxiety Symptoms Among Patients: A Systematic Review

TL;DR: Exercise training reduces anxiety symptoms among sedentary patients who have a chronic illness and whether selected variables of theoretical or practical importance moderate the effect is determined.
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Biological and Psychosocial Predictors of Postpartum Depression: Systematic Review and Call for Integration

TL;DR: A systematic review of research published from 2000 through 2013 on biological and psychosocial factors associated with PPD and postpartum depressive symptoms found the strongest PPD risk predictors are hypothalamic-pituitary-adrenal dysregulation, inflammatory processes, and genetic vulnerabilities.
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Novel melatonin-based therapies: potential advances in the treatment of major depression

TL;DR: This review highlights agomelatine, a melatonin-receptor agonist and selective serotonergic receptor subtype (ie, 5-HT(2C)) antagonist that has chronobiotic, antidepressant, and anxiolytic effects and outlines new antidepressant treatment strategies that target the circadian system.
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Insomnia and Daytime Sleepiness Are Risk Factors for Depressive Symptoms in the Elderly

TL;DR: Insomnia symptoms, EDS, and the use of medication independently increase the risk of subsequent depression in the elderly, and disturbed sleep and prolonged use of sleep medication may be early indicators or potentially reversible risk factors for depression.
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Bright-light therapy in the treatment of mood disorders.

TL;DR: The authors present a comprehensive overview of the literature on BLT in mood disorders and discusses the pathophysiology and clinical specifiers of SAD, which can be seen as a model disorder for chronobiological disturbances and the mechanism of action of BLT.
References
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Journal ArticleDOI

Epidemiologic study of sleep disturbances and psychiatric disorders : an opportunity for prevention

TL;DR: As part of the National Institute of Mental Health Epidemiologic Catchment Area study, 7954 respondents were questioned at baseline and 1 year later about sleep complaints and psychiatric symptoms using the Diagnostic Interview Schedule.
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Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice

TL;DR: Estimation of transcripts encoding selected hypothalamic peptides associated with energy balance was attenuated in the Clock mutant mice, suggesting that the circadian clock gene network plays an important role in mammalian energy balance.
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Seasonal Affective Disorder: A Description of the Syndrome and Preliminary Findings With Light Therapy

TL;DR: Preliminary studies in 11 patients suggest that extending the photoperiod with bright artificial light has an antidepressant effect and sleep recordings in nine depressed patients confirmed the presence of hypersomnia and showed increased sleep latency and reduced slow-wave (delta) sleep.
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Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms

TL;DR: It is suggested that the SCN contains a large population of autonomous, single-cell circadian oscillators, and that synapses formed in vitro are neither necessary for operation of these oscillators nor sufficient for synchronizing them.
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