The Contribution of Angiogenesis to the Process of Metastasis.
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TLDR
The role of angiogenesis as a necessity for the escape of tumor cells into the bloodstream and for the establishment of metastatic colonies in secondary sites is focused on.Abstract:
The role of angiogenesis in tumor growth has been studied continuously for over 45 years. It is now appreciated that angiogenesis is also essential for the dissemination and establishment of tumor metastases. In this review, we focus on the role of angiogenesis as a necessity for the escape of tumor cells into the bloodstream and for the establishment of metastatic colonies in secondary sites. We also discuss the role of tumor lymphangiogenesis as a means of dissemination of lymphatic metastases. Appropriate combination therapies may be used in the future to both prevent and treat metastatic disease through the rational use of antiangiogenic and antilymphangiogenic therapies in ways that are informed by the current and future work in the field.read more
Citations
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Role of Matrix Metalloproteinases in Angiogenesis and Cancer.
Saray Quintero-Fabián,Rodrigo Arreola,Enrique Becerril-Villanueva,Julio César Torres-Romero,Victor Arana-Argáez,Julio Lara-Riegos,Mario Alberto Ramírez-Camacho,María Elizbeth Alvarez-Sánchez +7 more
TL;DR: This review analyzes recent knowledge on MMPs and their participation in angiogenesis through the modulation of the balance between pro- and anti-angiogenic factors and concludes that Matrix metalloproteinases participate in the disruption, tumor neovascularization, and subsequent metastasis.
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Circular RNA MYLK as a competing endogenous RNA promotes bladder cancer progression through modulating VEGFA/VEGFR2 signaling pathway
TL;DR: It is demonstrated for the first time that circRNA-MYLK might function as competing endogenous RNA (ceRNA) for miR-29a, which could contribute to EMT and the development of BC through activating VEGFA/VEGFR2 and downstream Ras/ERK signaling pathway.
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Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
TL;DR: The evidence for the pharmacological potential and inhibition of quercetin on cancers, supporting the viewpoint that quercETin should be adequately considered as a therapeutic agent against various cancers is summarized.
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Regulators of angiogenesis
TL;DR: The molecules that regulate the process of angiogenesis, defined as the formation of new capillary vessels from existent microvessels, which plays a major role in the evolvement of a vascular supply in tissue during development or remodeling and disease is summarized.
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An Updated Review on Marine Anticancer Compounds: The Use of Virtual Screening for the Discovery of Small-Molecule Cancer Drugs
Verónica Ruiz-Torres,José Antonio Encinar,María Herranz-López,Almudena Pérez-Sánchez,Vicente Galiano,Enrique Barrajón-Catalán,Vicente Micol,Vicente Micol +7 more
TL;DR: This review gives an overview of MNPs, both in research or clinical stages, from diverse organisms that were reported as being active or potentially active in cancer treatment in the past seventeen years and describes their putative mechanisms of action.
References
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TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
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Tumor Angiogenesis: Therapeutic Implications
TL;DR: This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in 2016 and is likely to be accompanied by neovascularization.
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Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis
TL;DR: The work from the authors' laboratories reviewed herein was supported by grants from the National Cancer Institute.
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