Journal ArticleDOI
The distribution of the numbers of mutants in bacterial populations.
D. E. Lea,C. A. Coulson +1 more
TLDR
Statistical calculations are made of the distribution numbers of mutants in a culture of bacteria in which the number of mutants increases on account of new mutations and of division of old mutants, which enable the mutation rate to be inferred from experiments with parallel cultures.Abstract:
Statistical calculations are made of the distribution numbers of mutants in a culture of bacteria in which the number of mutants increases on account both of new mutations and of division of old mutants. In this way the largely qualitative conclusions of Luria and Delbruck are extended and placed on a firm quantitative basis. The results of these calculations, which enable the mutation rate to be inferred from experiments with parallel cultures, are presented in the form of tables. Statistically efficient methods of using these tables are discussed.read more
Citations
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The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer.
Richard Fishel,Mary Kay Lescoe,M.R.S. Rao,Neal G. Copeland,Nancy A. Jenkins,Judy Garber,Michael F. Kane,Richard D. Kolodner +7 more
TL;DR: Data and reports indicating that S. cerevisiae msh2 mutations cause an instability of dinucleotide repeats like those associated with H NPCC suggest that hMSH2 is the HNPCC gene.
Journal ArticleDOI
Elevated recombination rates in transcriptionally active DNA.
TL;DR: Northern analysis of strains containing plasmid inserts with various promoter mutations suggests that the stimulation in recombination is mediated by events initiating within the integrated plasmID sequences.
Journal ArticleDOI
Replica plating and indirect selection of bacterial mutants
TL;DR: An approach to this problem that makes use of a replica plating technique which facilitates the handling of large numbers of bacterial clones for classification on a variety of media is concerned.
Journal ArticleDOI
Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair
TL;DR: It is shown that mutations in any three yeast genes involved in DNA mismatch repair lead to 100- to 700-fold increases in tract instability, whereas mutations that eliminate the proof-reading function of DNA polymerases have little effect.
Journal ArticleDOI
The origin of mutants
TL;DR: Some experiments suggesting that cells may have mechanisms for choosing which mutations will occur are described, and the source of this idea is briefly reviewed.
References
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Journal ArticleDOI
Mutations of bacteria from virus sensitivity to virus resistance
Salvador E. Luria,Max Delbrück +1 more
TL;DR: This article reported Luria and Delbruck's breakthrough study in which they established that viruses do not induce mutations in bacteria, but that virus-resisting mutations are spontaneous.
Journal ArticleDOI
Production of Staphylococcus Strains Resistant to Various Concentrations of Penicillin.
TL;DR: The purpose of this study was to make a quantitative survey of the origin of resistant bacteria, and to clarify the genetic aspect of the mechanism through which resistance is formed.
Journal ArticleDOI
Inherited Differences in Sensitivity to Radiation in Escherichia Coli.
TL;DR: A mutation in Escherichisa Coli leading to resistance to both ultraviolet radiation and x-rays is reported, which was detected by exposing samples from normal cultures to high doses of radiation.