The Drosophila larva as a model for studying chemosensation and chemosensory learning: a review
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TLDR
It is argued that the simplicity of the larval chemosensory system, combined with the experimental accessibility of Drosophila on the genetic, electrophysiological, cellular, and behavioral level, makes this system suitable for an integrated understanding of chemosensation and chemos Sensory learning.Abstract:
Understanding the relationship between brain and behavior is the fundamental challenge in neuroscience. We focus on chemosensation and chemosensory learning in larval Drosophila and review what is known about its molecular and cellular bases. Detailed analyses suggest that the larval olfactory system, albeit much reduced in cell number, shares the basic architecture, both in terms of receptor gene expression and neuronal circuitry, of its adult counterpart as well as of mammals. With respect to the gustatory system, less is known in particular with respect to processing of gustatory information in the central nervous system, leaving generalizations premature. On the behavioral level, a learning paradigm for the association of odors with food reinforcement has been introduced. Capitalizing on the knowledge of the chemosensory pathways, we review the first steps to reveal the genetic and cellular bases of olfactory learning in larval Drosophila. We argue that the simplicity of the larval chemosensory system, combined with the experimental accessibility of Drosophila on the genetic, electrophysiological, cellular, and behavioral level, makes this system suitable for an integrated understanding of chemosensation and chemosensory learning.read more
Citations
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Drosophila olfactory memory: single genes to complex neural circuits
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TL;DR: A central goal of neuroscience is to understand how neural circuits encode memory and guide behaviour, and simple, genetically tractable organisms, such as Drosophila melanogaster, can illuminate principles of neural circuit organization and function.
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Drosophila Chemoreceptors: A Molecular Interface Between the Chemical World and the Brain.
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TL;DR: This work considers recent progress in understanding chemoreception in the fly, including the identification of new receptors, the discovery of novel biological functions for receptors, and the localization of receptors in unexpected places.
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Active sampling and decision making in Drosophila chemotaxis.
TL;DR: It is shown that chemotaxis in Drosophila melanogaster larvae is an active sampling process analogous to sniffing in vertebrates, and it is suggested that larvalChemotaxis represents an intermediate navigation strategy between the biased random walks of Escherichia Coli and the stereo-olfaction observed in rats and humans.
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The role of dopamine in Drosophila larval classical olfactory conditioning
TL;DR: The anatomy and function of the larval dopaminergic system is analyzed, it is found that dopamine receptors are highly enriched in the mushroom bodies and that aversive and appetitive olfactory learning is strongly impaired in dopamine receptor mutants.
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The wiring diagram of a glomerular olfactory system.
Matthew E. Berck,Avinash Khandelwal,Avinash Khandelwal,Lindsey Claus,Luis Hernandez-Nunez,Guangwei Si,Christopher J. Tabone,Feng Li,James W Truman,Richard D. Fetter,Matthieu Louis,Matthieu Louis,Aravinthan D. T. Samuel,Albert Cardona +13 more
TL;DR: This complete wiring diagram of the Drosophila larval antennal lobe is mapped with electron microscopy and putatively implement a bistable gain control mechanism that either computes odor saliency through panglomerular inhibition, or allows some glomeruli to respond to faint aversive odors in the presence of strong appetitive odors.
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