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The effect of arsenate on aerobic phosphorylation.

Robert K. Crane, +1 more
- 01 Mar 1953 - 
- Vol. 201, Iss: 1, pp 235-243
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This article is published in Journal of Biological Chemistry.The article was published on 1953-03-01 and is currently open access. It has received 498 citations till now. The article focuses on the topics: Arsenate & Arsenic.

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Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase.

TL;DR: Aurovertin, an inhibitor of oxidative phosphorylation, enhanced Pi binding via a 4-fold increase in the affinity of the enzyme for Pi (KD = 20 micronM) but did not alter binding stoichiometry.
Journal ArticleDOI

Arsenic toxicity and potential mechanisms of action

TL;DR: A better understanding of the mechanism(s) of action) of arsenic will make a more confident determination of the risks associated with exposure to this chemical.
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Arsenic Exposure and Toxicology: A Historical Perspective

TL;DR: The mode of action of arsenic for its disease endpoints is currently under study, and two key areas are the interaction of trivalent arsenicals with sulfur in proteins and the ability of arsenic to generate oxidative stress.
Journal ArticleDOI

Membrane adenosine triphosphatase as a participant in the active transport of sodium and potassium in the human erythrocyte.

TL;DR: Evidence is presented that an adenosine triphosphatase in broken human erythrocyte membranes is a part of the system for the active transport of sodium and potassium in intact ery Throthrocytes.
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Activation by Adenosine Triphosphate in the Phosphorylation Kinetics of Sodium and Potassium Ion Transport Adenosine Triphosphatase

TL;DR: It was concluded that adenosine triphosphate was activating the enzyme in a fashion functionally distinct from its action as a phosphate donor, since the concentration of adenosines triph phosphate required for activation was much higher than that required for phosphorylation.
References
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Manometric techniques and related methods for the study of tissue metabolism.

TL;DR: This book has been designed to give the graduate JL student a working description of the methods used as a routine in the study of tissue metabolism and only methods which are likely to need the minimum equipment found normally in a biological laboratory such as a respirometer, colorimeter and centrifuge are described.
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Coenzyme A function in and acetyl transfer by the phosphotransacetylase system.

TL;DR: Attempts to identify this “activator” function of microbial extracts led to the proposition that the phosphate exchange and arsenolysis system may be responsible for the acetyl transfer from acetyl phosphate.
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