Journal ArticleDOI
The effect of formulation parameters on the size of poly((2-dimethylamino)ethyl methacrylate)-plasmid complexes
TLDR
A mathematical model was derived, which shows that even at high plasmid concentration, small sized polyplexes were formed at low pH and ionic strength, especially when the solution contains 20% (w/v) sucrose.About:
This article is published in European Journal of Pharmaceutics and Biopharmaceutics.The article was published on 1999-05-01. It has received 63 citations till now. The article focuses on the topics: Ionic strength.read more
Citations
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Polymer-based siRNA delivery: Perspectives on the fundamental and phenomenological distinctions from polymer-based DNA delivery
TL;DR: How some of the remaining challenges in siRNA delivery facilitated by polymers can be addressed by applying knowledge from the longer-studied problem of DNA delivery is discussed.
Journal ArticleDOI
Polyelectrolyte complex formation using alginate and chitosan
TL;DR: In this article, polyelectrolyte complexes (PECs) of alginate and chitosan were formed by adding 0.1% alginates solution (pH ∼6.5), and by adding the Chitosans solution to the Alginate solution under high shearing conditions, and the resultant PEC size, Zp, and pH were determined using dynamic light scattering (DLS), electrophoresis and by measuring turbidity and pH.
Journal ArticleDOI
PDMAEMA based gene delivery materials
TL;DR: Recent efforts in design, synthesis, and performance of poly(2-dimethylaminoethyl methacrylate) (PDMAEMA) nanocomplexes with DNA are discussed.
Journal ArticleDOI
Optimizing drug delivery systems using systematic "design of experiments." Part II: retrospect and prospects.
TL;DR: A vast account of various DoE reports on optimization of diverse drug delivery system and processes along with the critical graphical analysis of various designs, input, and response variables have been presented here in a categorical form.
Journal ArticleDOI
Multivariate methods in pharmaceutical applications
TL;DR: This review covers material published within the field of pharmacy in the last five years concerning experimental design, optimization and applications of multivariate techniques, from factorial designs to multivariate data analysis, and the combination of the two in multivariate design.
References
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Book
Empirical Model-Building and Response Surfaces
TL;DR: In this article, the authors present a Second-Order Response Surface Methodology (SRSM) for response surface design, which is based on Maxima and Ridge systems with second-order response surfaces.
Journal ArticleDOI
Empirical Model-Building and Response Surfaces
TL;DR: This work discusses the use of Graduating Functions, design Aspects of Variance, Bias, and Lack of Fit, and Practical Choice of a Response Surface Design in relation to Second--Order Response Surfaces.
Journal ArticleDOI
The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes
TL;DR: At the concentrations studied, these polymers interact electrostatically with DNA forming a unit structure with toroidal morphology; the extent of aggregation of the unit structures in solution depends upon the characteristics of the individual polymer.