Journal ArticleDOI
The effects of zinc treatment on matrix metalloproteinases: A systematic review.
TLDR
The inhibitory or stimulatory effect of Zn on MMPs seems to depend on physiological conditions of the cells or animals used, dose ofZn used, and duration of treatment.About:
This article is published in Journal of Trace Elements in Medicine and Biology.The article was published on 2019-12-01. It has received 18 citations till now.read more
Citations
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Journal ArticleDOI
Icariside II attenuates cerebral ischemia/reperfusion-induced blood–brain barrier dysfunction in rats via regulating the balance of MMP9/TIMP1
TL;DR: Findings reveal that ICS II significantly ameliorates I/R-induced BBB disruption and neuronal apoptosis in MCAO rats by regulating the MMP9/TIMP1 balance and inhibiting the caspase 3-dependent apoptosis pathway.
Journal ArticleDOI
Improved Blood Compatibility and Endothelialization of Titanium Oxide Nanotube Arrays on Titanium Surface by Zinc Doping.
Changjiang Pan,Youdong Hu,Gong Zhihao,Ya Yang,Sen Liu,Li Quan,Zhongmei Yang,Yanchun Wei,Wei Ye +8 more
TL;DR: The zinc doped titanium dioxide nanotube array can be used to simultaneously improve the blood compatibility and promote endothelialization of the titanium-based biomaterials and implants, such as intravascular stents.
Journal ArticleDOI
Role of intracellular zinc in molecular and cellular function in allergic inflammatory diseases.
Masanobu Suzuki,Takayoshi Suzuki,Masashi Watanabe,Shigetsugu Hatakeyama,Shogo Kimura,Akira Nakazono,Aya Honma,Yuji Nakamaru,Sarah Vreugde,Akihiro Homma +9 more
TL;DR: Recent evidence on the involvement of zinc in atopic dermatitis, bronchial asthma, and chronic rhinosinusitis is presented, with insights into the involvement in the underlying molecular and cellular mechanisms related to these allergic inflammatory diseases.
Journal ArticleDOI
Corilagin ameliorates atherosclerosis by regulating MMP-1, -2, and -9 expression in vitro and in vivo.
Yiting Tao,Zhang Li,Yang Renhua,Yongzhao Yang,Haonan Jin,Zhang Xiaochao,Qin Hu,Bo He,Shen Zhiqiang,Chen Peng +9 more
TL;DR: In this article, the anti-atherosclerotic effects and the underlying mechanisms of corilagin were evaluated and it was shown that Corilagin treatment significantly reduced the degree of injury in the common carotid artery and decreased the number of lipid plaques and foam cells.
Journal ArticleDOI
Regenerative Activities of ROS-Modulating Trace Metals in Subcutaneously Implanted Biodegradable Cryogel
TL;DR: The results specify and compare the prooxidant and regenerative potential of Cu, Co and Zn-doped biodegradable cryogels and are of particular interest for the development of advanced bioinductive hydrogel materials for controlling angiogenesis and soft tissue growth.
References
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Journal ArticleDOI
Matrix Metalloproteinases: A Review
Henning Birkedal-Hansen,William G. I. Moore,M.K. Bodden,L.J. Windsor,B. Birkedal-Hansen,Arthur A. Decarlo,Jeffrey A. Engler +6 more
TL;DR: The present review discusses in detail the primary structures and the overlapping yet distinct substrate specificities of MMPs as well as the mode of activation of the unique MMP precursors.
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Structure and function of matrix metalloproteinases and TIMPs
TL;DR: The members of the MMP family are introduced and their domain structure and function, proenyme activation, the mechanism of inhibition by TIMPs and their significance in physiology and pathology are discussed.
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Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations
TL;DR: The studies that brought MPIs into clinical testing are reviewed and the design and outcome of the trials are discussed in light of new information about the cellular source, substrates, and mode of action of MMPs at different stages of tumor progression.
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Changing Views of the Role of Matrix Metalloproteinases in Metastasis
TL;DR: A new view of the functional role of M MPs in metastasis is presented, which suggests that MMPs are important in creating and maintaining an environment that supports the initiation and maintenance of growth of primary and metastatic tumors.
Journal Article
Tissue inhibitors of metalloproteinases: structure, regulation and biological functions.
TL;DR: The main aim of this article is to review recent literature on TIMPs with special emphasis on their biological activities and the possibility that they may have paradoxical roles in tumor progression.