Journal ArticleDOI
The epidemiology of human papillomavirus infections.
TLDR
Significant issues surrounding the natural history of HPV infection, including viral persistence versus clearance, immune response, development of lesions and development of cancer are discussed.About:
This article is published in Journal of Clinical Virology.The article was published on 2005-03-01. It has received 990 citations till now. The article focuses on the topics: Genital warts & HPV infection.read more
Citations
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Journal ArticleDOI
Human papillomavirus and cervical cancer
TL;DR: The new HPV-oriented model of cervical carcinogenesis should gradually replace older morphological models based only on cytology and histology, and can minimise the incidence of cervical cancer, and the morbidity and mortality it causes, even in low-resource settings.
Journal ArticleDOI
The biology and life-cycle of human papillomaviruses.
John Doorbar,Wim Quint,Lawrence Banks,Ignacio G. Bravo,Mark H. Stoler,Tom R. Broker,Margaret Stanley +6 more
TL;DR: The high-risk HPV types are a cause of several important human cancers, including almost all cases of cervical cancer, a large proportion of other anogenital cancers and a growing number of head and neck tumours.
Journal ArticleDOI
The epidemiology of genital human papillomavirus infection.
Helen Trottier,Eduardo L. Franco +1 more
TL;DR: Persistent infection with HR-HPVs is now unequivocally established as a necessary cause of cervical cancer and is likely to be responsible for a substantial proportion of other anogenital neoplasms and upper aero-digestive tract cancers.
Journal ArticleDOI
Human papillomavirus molecular biology and disease association
TL;DR: Most work to date has focused on the study of high‐risk HPV types such as HPV 16 and 18, which has led to an understanding of the molecular pathways subverted by these viruses, which will lead to better strategies for disease treatment, including targeted antivirals and immunotherapeutics.
Epidemiology and transmission dynamics of genital HPV infection
TL;DR: This chapter provides an overview of the epidemiology of human papillomavirus (HPV) infection, with a focus on the dynamics of sexual transmission, and the implications of transmission dynamics for the success of future HPV vaccines are discussed.
References
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Journal ArticleDOI
Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase
Randall Keichi Saiki,David H. Gelfand,Susanne Stoffel,Stephen J. Scharf,Russell Higuchi,Glenn Thomas Horn,Kary B. Mullis,Henry A. Erlich +7 more
TL;DR: A thermostable DNA polymerase was used in an in vitro DNA amplification procedure, the polymerase chain reaction, which significantly improves the specificity, yield, sensitivity, and length of products that can be amplified.
Journal ArticleDOI
Human papillomavirus is a necessary cause of invasive cervical cancer worldwide.
Jan M. M. Walboomers,M. V. Jacobs,M. M. Manos,Franz X. Bosch,J. A. Kummer,Keerti V. Shah,Peter J.F. Snijders,Julian Peto,Chris J.L.M. Meijer,Nubia Muñoz +9 more
TL;DR: The presence of HPV in virtually all cervical cancers implies the highest worldwide attributable fraction so far reported for a specific cause of any major human cancer, and the rationale for HPV testing in addition to, or even instead of, cervical cytology in routine cervical screening.
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Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical Cancer
Nubia Muñoz,F. Xavier Bosch,Silvia de Sanjosé,Rolando Herrero,Xavier Castellsagué,Keerti V. Shah,Peter J.F. Snijders,Chris J.L.M. Meijer +7 more
TL;DR: In addition to HPV types 16 and 18, types 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, and 82Should be considered carcinogenic, or high-risk, types, and types 26, 53, and 66 should be considered probably carcinogenic.
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Prevalence of Human Papillomavirus in Cervical Cancer: a Worldwide Perspective
Francesc Xavier Bosch,M. M. Manos,Nubia Muñoz,Mark E. Sherman,Angela M. Jansen,Julian Peto,Mark Schiffman,Victor Moreno,Robert J. Kurman,Keerti V. Shah +9 more
TL;DR: The results confirm the role of genitalHPVs, which are transmitted sexually, as the central etiologic factor in cervical cancer worldwide and suggest that most genital HPVs are associated with cancer, at least occasionally.