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The Exocrine Pancreas
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TLDR
This chapter describes the neurohumoral pathways that mediate the pancreatic response to a meal as well as details of the cellular mechanisms that are necessary for the organ responses, including protein synthesis and transport and ion transports, and the regulation of these responses by intracellular signaling systems.Abstract:
The secretions of the exocrine pancreas provide for digestion of a meal into components that are then available for processing and absorption by the intestinal epithelium. Without the exocrine pancreas, malabsorption and malnutrition result. This chapter describes the cellular participants responsible for the secretion of digestive enzymes and fluid that in combination provide a pancreatic secretion that accomplishes the digestive functions of the gland. Key cellular participants, the acinar cell and the duct cell, are responsible for digestive enzyme and fluid secretion, respectively, of the exocrine pancreas. This chapter describes the neurohumoral pathways that mediate the pancreatic response to a meal as well as details of the cellular mechanisms that are necessary for the organ responses, including protein synthesis and transport and ion transports, and the regulation of these responses by intracellular signaling systems. Examples of pancreatic diseases resulting from dysfunction in cellular...read more
Citations
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Journal ArticleDOI
Acute Pancreatitis: A Multifaceted Set of Organelle and Cellular Interactions
TL;DR: Emerging findings that stressors that cause acute pancreatitis initially cause injury to organelles of the acinar cell (endoplasmic reticulum, mitochondria, and endolysosomal-autophagy system) are emphasized and considered to create a discussion for clinical trial treatment and design options.
Journal ArticleDOI
Unraveling the complex genetic model for cystic fibrosis: pleiotropic effects of modifier genes on early cystic fibrosis-related morbidities
Weili Li,Weili Li,David Soave,David Soave,Melissa R. Miller,Katherine Keenan,Fan Lin,Jiafen Gong,Theodore Chiang,Anne L. Stephenson,Anne L. Stephenson,Peter R. Durie,Peter R. Durie,Johanna M. Rommens,Johanna M. Rommens,Lei Sun,Lisa J. Strug,Lisa J. Strug +17 more
TL;DR: The existence of pleiotropic effects within this single disorder suggests that complementary therapeutic strategies to augment solute transport will benefit multiple CF-associated tissues.
Journal ArticleDOI
Exocrine pancreatic insufficiency in adults: A shared position statement of the Italian association for the study of the pancreas
Raffaele Pezzilli,Angelo Andriulli,Claudio Bassi,Gianpaolo Balzano,Maurizio Cantore,Gianfranco Delle Fave,Massimo Falconi,Luca Frulloni +7 more
TL;DR: The main diseases associated with exocrine pancreatic insufficiency (EPI) which are of common interest to internists/gastroenterologists, oncologists and surgeons are covered, fully aware that EPI may also occur together with many other diseases, but less frequently.
Journal ArticleDOI
Abnormalities of the Exocrine Pancreas in Type 1 Diabetes
TL;DR: Evidence is collected that supports the hypothesis that T1D is a combined endocrine-exocrine disease in which the loss of functional beta cell mass is most clinically apparent, and that this loss is secondary to beta cell loss.
Journal ArticleDOI
The Emerging Role of Smoking in the Development of Pancreatitis
TL;DR: Specific constituents of cigarette smoke, including nicotine and its metabolites, could mediate effects on the pancreas, and may be alcohol independent but synergize with alcohol.
References
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