The Expression Profile and Prognostic Significance of Metallothionein Genes in Colorectal Cancer.
Kuo Chen Hung,Tsui Chin Huang,Chia Hsiung Cheng,Ya Wen Cheng,Ding Yen Lin,Ding Yen Lin,Jhen Jia Fan,Jhen Jia Fan,Kuen Haur Lee +8 more
TLDR
This study is the first to report that simultaneous downregulation of six MT mRNAs’ levels in CRC patients, and their aberrant expression together, accurately predicted CRC patients’ outcomes.Abstract:
Colorectal cancer (CRC) is a heterogeneous disease resulting from the combined influence of many genetic factors. This complexity has caused the molecular characterization of CRC to remain uncharacterized, with a lack of clear gene markers associated with CRC and the prognosis of this disease. Thus, highly sensitive tumor markers for the detection of CRC are the most essential determinants of survival. In this study, we examined the simultaneous downregulation of the mRNA levels of six metallothionein (MT) genes in CRC cell lines and public CRC datasets for the first time. In addition, we detected downregulation of these six MT mRNAs’ levels in 30 pairs of tumor (T) and adjacent non-tumor (N) CRC specimens. In order to understand the potential prognostic relevance of these six MT genes and CRC, we presented a four-gene signature to evaluate the prognosis of CRC patients. Further discovery suggested that the four-gene signature (MT1F, MT1G, MT1L, and MT1X) predicted survival better than any combination of two-, three-, four-, five-, or six-gene models. In conclusion, this study is the first to report that simultaneous downregulation of six MT mRNAs’ levels in CRC patients, and their aberrant expression together, accurately predicted CRC patients’ outcomes.read more
Citations
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UBE2S activates NF-κB signaling by binding with IκBα and promotes metastasis of lung adenocarcinoma cells
TL;DR: Higher UBE2S expressed in lung adenocarcinomas could bind with IκBα for activation of NF-κB signaling to promote metastasis of cancer cells and might be a potential therapeutic target for lungAdenocARCinomas.
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Overexpressed pseudogene MT1L associated with tumor immune infiltrates and indicates a worse prognosis in BLCA
Yanpeng Ding,Nuomin Liu,Mengge Chen,Yulian Xu,Sha Fang,Wenbin Xiang,Xinying Hua,Gaili Chen,Yahua Zhong,Haijun Yu +9 more
TL;DR: It is demonstrated that pseudogene MT1L regulates the immune microenvironment, correlates with poor survival, and serves as an independent prognostic biomarker in BLCA.
Journal ArticleDOI
Identification of MT1E as a novel tumor suppressor in hepatocellular carcinoma.
Qicheng Liu,Feng Lu,Zhong Chen +2 more
TL;DR: The results suggested that epigenetic silencing of MT1E due to promoter hypermethylation could play a vital role in HCC, and verified thatMT1E suppressed cell growth in vitro and vivo.
Journal ArticleDOI
Expression Profile and Prognostic Value of Wnt Signaling Pathway Molecules in Colorectal Cancer
Yung-Fu Wu,Chih-Yang Wang,Wan-Chun Tang,Yu-Cheng Lee,Hoang Dang Khoa Ta,Li-Chia Lin,Syu-Ruei Pan,Yi-Chun Ni,Gangga Anuraga,Kuen Haur Lee +9 more
TL;DR: In this paper, the authors demonstrate that high mRNA levels of 10 upregulated genes (DPEP1, KRT80, FABP6, NKD2, FOXQ1, CEMIP, ETV4, TESC, FUT1, and GAS2) are associated with worse prognosis in colorectal cancer patients.
Journal ArticleDOI
Molecular and Translational Research on Colorectal Cancer
TL;DR: Colorectal cancer (CRC) is the third most frequently diagnosed cancer in the world and in women it is the most common type of cancer.
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