The genetic evolution of canine parvovirus - A new perspective.
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TLDR
A summary of all VP2 sequences provides a new perspective regarding CPV-2 evolution and the correlative biological studies needs to be further performed.Abstract:
To trace the evolution process of CPV-2, all of the VP2 gene sequences of CPV-2 and FPV (from 1978 to 2015) from GenBank were analyzed in this study. Then, several new ideas regarding CPV-2 evolution were presented. First, the VP2 amino acid 555 and 375 positions of CPV-2 were first ruled out as a universal mutation site in CPV-2a and amino acid 101 position of FPV feature I or T instead of only I in existing rule. Second, the recently confusing nomenclature of CPV-2 variants was substituted with a optional nomenclature that would serve future CPV-2 research. Third, After check the global distribution of variants, CPV-2a is the predominant variant in Asia and CPV-2c is the predominant variant in Europe and Latin America. Fourth, a series of CPV-2-like strains were identified and deduced to evolve from modified live vaccine strains. Finally, three single VP2 mutation (F267Y, Y324I, and T440A) strains were caught concern. Furthermore, these three new VP2 mutation strains may be responsible for vaccine failure, and the strains with VP2 440A may become the novel CPV sub-variant. In conclusion, a summary of all VP2 sequences provides a new perspective regarding CPV-2 evolution and the correlative biological studies needs to be further performed.read more
Citations
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Introduction of Asian canine parvovirus in Europe through dog importation.
Francesco Mira,Giuseppa Purpari,Eleonora Lorusso,S. Di Bella,Francesca Gucciardi,Costantina Desario,Giusi Macaluso,Nicola Decaro,Annalisa Guercio +8 more
TL;DR: The genomic characterization of a CPV strain collected from a dog recently imported to Italy from Thailand confirmed the important role of movement of dogs in the global spread of viruses, as well as helping to better trace the spread of canine viruses through different continents.
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Spreading of canine parvovirus type 2c mutants of Asian origin in southern Italy
Francesco Mira,Giuseppa Purpari,Santina Di Bella,Maria Loredana Colaianni,Giorgia Schirò,Gabriele Chiaramonte,Francesca Gucciardi,Patrizia Pisano,Antonio Lastra,Nicola Decaro,Annalisa Guercio +10 more
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Advances in Veterinary Science and Comparative Medicine.
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Molecular typing of a novel canine parvovirus type 2a mutant circulating in Italy.
Francesco Mira,Giulia Dowgier,Giuseppa Purpari,Domenico Vicari,Santina Di Bella,Giusi Macaluso,Francesca Gucciardi,Vincenzo Randazzo,Nicola Decaro,Annalisa Guercio +9 more
TL;DR: This study represents the first evidence of a newCPV-2a mutant (VP2 324Leu) and illustrates the importance of a continuous molecular survey in order to obtain more information on effective spread of new CPV mutants.
References
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High rate of viral evolution associated with the emergence of carnivore parvovirus
TL;DR: Although FPLV has remained an endemic infection in its host populations, it is shown that, since the 1970s, the newly emerged CPV has undergone an epidemic-like pattern of logistic/exponential growth, effectively doubling its population size every few years.
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TL;DR: Two isolates of canine parvovirus (CPV) were obtained from dogs affected with severe haemorrhagic diarrhoea, and the failure of established typing methods to distinguish this antigenic variant was overcome by the development of an RFLP assay.
Journal ArticleDOI
The three-dimensional structure of canine parvovirus and its functional implications
Jun Tsao,Michael Chapman,Mavis Agbandje,Walter Keller,Kathy Smith,Hao Wu,Ming Luo,Thomas J. Smith,Michael G. Rossmann,Richard W. Compans,Colin R. Parrish +10 more
TL;DR: The three-dimensional atomic structure of a single-stranded DNA virus has been determined and some of the amino termini of VP-2 run to the exterior in full but not empty virions, which is consistent with the observation that someVP-2 polypeptides in full particles can be cleaved by trypsin.
Journal ArticleDOI
Rapid antigenic-type replacement and DNA sequence evolution of canine parvovirus
Colin R. Parrish,Charles F. Aquadro,M L Strassheim,James F. Evermann,Jean-Yves Sgro,H O Mohammed +5 more
TL;DR: Analysis of canine parvovirus (CPV) isolates with a panel of monoclonal antibodies showed that after 1986, most viruses isolated from dogs in many parts of the United States differed antigenically from the viruses isolated prior to that date, leading to a progressive evolution away from the original CPV type.
Journal ArticleDOI
Canine parvovirus—A review of epidemiological and diagnostic aspects, with emphasis on type 2c
Nicola Decaro,Canio Buonavoglia +1 more
TL;DR: Investigations indicate that the newest type CPV-2c is becoming prevalent in different geographic regions and is often associated to severe disease in adult dogs and also in dogs that have completed the vaccination protocols, and continuous surveillance will help assess whether there is a real need to update currently available vaccines and diagnostic tests.
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