Journal ArticleDOI
The genome of Uukuniemi virus consists of three unique RNA segments
TLDR
The presence of a 5' terminal pppAp structure in each RNA segment confirms indications from electron microscopy that the apparently circular RNA segments are not covalently closed, and supports the concept that Uukuniemi virus is a negative strand virus.About:
This article is published in Cell.The article was published on 1977-05-01. It has received 64 citations till now. The article focuses on the topics: Uukuniemi virus & RNA.read more
Citations
More filters
Journal ArticleDOI
Molecular biology of the bunyaviridae
TL;DR: Hantaan and related viruses, the causative agents of haemorrhagic fever with renal syndrome, are now recognized as belonging to the Bunyaviridae and cause a severe haem orrhagic disease with significant mortality throughout Asia, especially in China.
Journal ArticleDOI
The origins of defective interfering particles of the negative-strand RNA viruses
TL;DR: The present understanding of negative-strand RNA virus replication is summarized and the replicative event leading to the generation of defective interfering (DI) particles is examined.
Journal ArticleDOI
Ultrastructural characteristics of Sin Nombre virus, causative agent of hantavirus pulmonary syndrome.
TL;DR: The morphologic features of the causative agent, Sin Nombre virus (SNV), are studied by thin section electron microscopy and immunoelectron microscopy of infected Vero E6 cells and viral antigens were localized over virions, inclusions, and tubular projections associated with virion morphogenesis.
Journal ArticleDOI
Rubella virus 40S genome RNA specifies a 24S subgenomic mRNA that codes for a precursor to structural proteins.
TL;DR: The results suggest that the 24S RNA species represents a subgenomic mRNA coding for a precursor to the structural proteins of rubella virus, which appears to be similar to that of the alphaviruses.
Journal ArticleDOI
Uukuniemi virus maturation: accumulation of virus particles and viral antigens in the Golgi complex.
TL;DR: The results indicate that Uukuniemi virus and its structural proteins accumulate in the Golgi complex, supporting the idea that this compartment rather than the plasma membrane is the site of virus maturation.
References
More filters
Journal ArticleDOI
Detection of two restriction endonuclease activities in Haemophilus parainfluenzae using analytical agarose--ethidium bromide electrophoresis
Journal ArticleDOI
Molecular weight estimation and separation of ribonucleic acid by electrophoresis in agarose-acrylamide composite gels
A C Peacock,C W Dingman +1 more
Journal ArticleDOI
The determination of the molecular weight of ribonucleic acid by polyacrylamide-gel electrophoresis. The effects of changes in conformation
TL;DR: It is concluded that the method provides a satisfactory measurement of molecular weight, which is almost independent of the nucleotide composition of RNA at moderate salt concentrations.
Journal ArticleDOI
Expression of Animal Virus Genomes
TL;DR: A scheme is presented and the behavior of three viral systems which have been investigated in my laboratory are discussed and some of the implications of the existence of these viral systems in the context of thebehavior of normal cells are discussed.
Journal ArticleDOI
Preparative two-dimensional polyacrylamide gel electrophoresis of 32P-labeled RNA
R. De Wachter,Walter Fiers +1 more
TL;DR: The method has been applied to the complete separation of RNA fractions obtained after a preliminary gel electrophoresis of partial enzymic digests of 32P-labeled bacteriophage RNA.