The IASLC Lung Cancer Staging Project: Analysis of Resection Margin Status and Proposals for Residual Tumor Descriptors for Non-Small Cell Lung Cancer.
John G. Edwards,Kari Chansky,Paul Van Schil,Andrew G. Nicholson,Souheil Boubia,Elisabeth Brambilla,Jessica S. Donington,Françoise Galateau-Sallé,Hans Hoffmann,Maurizio Infante,Mirella Marino,Edith M. Marom,Jun Nakajima,Marcin Ostrowski,William D. Travis,Ming-Sound Tsao,Yasushi Yatabe,Dorothy J. Giroux,Lynn Shemanski,John Crowley,Marc Krasnik,Hisao Asamura,Ramón Rami-Porta,Valerie W. Rusch,Luiz H. Araujo,David G. Beer,Pietro Bertoglio,Ricardo Beyruti,Andrea Billè,Vanessa Bolejack,James D. Brierley,Ayten Kayi Cangir,David P. Carbone,Gail Darling,Frank C. Detterbeck,Xavier Benoit D’Journo,Jessica Donnington,Wilfried Eberhardt,John Edwards,Jeremy J. Erasmus,Conrad Falkson,Wentao Fang,Dean A. Fennell,Kwun M. Fong,Oliver Gautschi,Ritu R. Gill,Dorothy Giroux,Meredith Giuliani,Jin Mo Goo,Seiki Hasegawa,Fred R. Hirsch,Hans Hoffman,Wayne L. Hofstetter,James Huang,Philippe Joubert,Kemp H. Kernstine,Keith M. Kerr,Young Tae Kim,Hong Kwan Kim,Hedy L. Kindler,Yolande Lievens,Hui Liu,Donald E. Low,Gustavo Lyons,Heber MacMahon,Edith Marom,José-María Matilla,Jan P. van Meerbeeck,Luis M. Montuenga,Andrew G. Nicholson,Katie Nishimura,Anna K. Nowak,Isabelle Opitz,Meinoshin Okumura,Raymond U. Osarogiagbon,Harvey I. Pass,Marc de Perrot,Helmut Prosch,David C. Rice,Andreas Rimner,Enrico Ruffini,Shuji Sakai,Navneet Singh,Amy Stoll-D’Astice,Francisco Su´rez,Ricardo Mingarini Terra,Ming S. Tsao,Paula A. Ugalde,David A. Waller,Shun-ichi Watanabe,Jacinta Wiens,Ignacio I. Wistuba,Liyan Jiang,Kaoru Kubota,Akif Turna,Benny Weksler,Maria Teresa Tzukazan,Martin C. Tammemägi,Charles A. Powell,David P. Naidich,Hongxu Liu,Samuel G. Armato,Alex Brunelli,Giuseppe Cardillo,Elizabeth A. David,Brigitte Fournier,Mark Krasnik,Kauro Kubota,Catherine Labbé,Eric Lim,Paul Martin Putora,Gaetano Rocco,Pier Luigi Filosso,Kazuya Kondo,Dong Kwan Kim,Giuseppe Giaccone,Marco Lucchi,Thomas W. Rice,Mark K. Ferguson,Prasad Adsusmilli,William D. Travis,Francisco Suárez,Kaura Kubota,Watanabe Hisao Asamura Shun-ichi,Rami-Porta Edith Marom Ramón,M. Tsao,Watanabe Ming Tsao Shun-ichi,Meredith Guiliani,James Brierley,Ricardo R. Terra,Ray Osarogiagbon,Luis M. Montuenga,Hong Wei Wang,Françoise Galateau,Jim Mo Goo,Bill Travis,José María Matilla,Carolle St. Pierre,Ma Teresa Tzukazan,Nicholas Girard,Andreas Rimmer,Prasad S. Adusumilli,Xavier D’Journo,Donald E. Low,Adam Rosenthal +144 more
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TLDR
R descriptors have prognostic relevance with R(un) survival stratifying between R0 and R1, and a detailed evaluation of R factor is of particular importance in the design and analyses of clinical trials of adjuvant therapies.About:
This article is published in Journal of Thoracic Oncology.The article was published on 2020-03-01 and is currently open access. It has received 77 citations till now. The article focuses on the topics: Resection margin & Lung cancer staging.read more
Citations
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ESMO expert consensus statements on the management of EGFR mutant Non-Small Cell Lung Cancer.
Antonio Passaro,NB Leighl,Fiona H Blackhall,Sanjay Popat,Kelsey Kerr,M. Ahn,Maria E. Arcila,Oscar Arrieta,David Planchard,Filippo de Marinis,A.-M. C. Dingemans,Rafal Dziadziuszko,Corinne Faivre-Finn,Jill Elizabeth Feldman,E. Felip,Giuseppe Curigliano,Roy S. Herbst,Pasi A. Jänne,Thomas John,Tetsuya Mitsudomi,Tony Mok,Nicola Normanno,Luiz Paz-Ares,S.S. Ramalingam,Lecia V. Sequist,Johan Vansteenkiste,Ignacio I. Wistuba,Jonathan Wolf,Y. Wu,S. Yang,J.C-H. Yang,Y. Yatabe,George Pentheroudakis,S. Peters +33 more
TL;DR: The European Society for Medical Oncology (ESMO) held a virtual consensus-building process on epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancer in 2021 as discussed by the authors .
Journal ArticleDOI
The IASLC Lung Cancer Staging Project: A Renewed Call to Participation
Dorothy J. Giroux,Paul Van Schil,Hisao Asamura,Ramón Rami-Porta,Kari Chansky,John J. Crowley,Valerie W. Rusch,Kemp H. Kernstine,V. Rusch,Luiz H. Araujo,Paul Beckett,David G. Beer,Pietro Bertoglio,Ricardo Beyruti,Andrea Billè,Vanessa Bolejack,Souheil Boubia,Elisabeth Brambilla,James Brierley,Ayten Kayi Cangir,David P. Carbone,John Crowley,Gail Darling,Frank C. Detterbeck,Xavier Benoit D’Journo,Jessica Donnington,Wilfried Eberhardt,John G. Edwards,Jeremy J. Erasmus,Wentao Fang,Dean A. Fennell,Kwun M. Fong,Françoise Galateau-Sallé,Oliver Gautschi,Ritu R. Gill,Dorothy Giroux,Jin Mo Goo,Seiki Hasegawa,Fred R. Hirsch,Hans Hoffman,Wayne L. Hofstetter,James Huang,Philippe Joubert,Keith M. Kerr,Young Tae Kim,Hong Kwan Kim,Hedy L. Kindler,Yolande Lievens,Hui Liu,Donald E. Low,Gustavo Lyons,Heber MacMahon,Mirella Marino,Edith M. Marom,José-María Matilla,Jan P. van Meerbeeck,Luis M. Montuenga,Andrew G. Nicholson,Anna K. Nowak,Isabelle Opitz,Meinoshin Okumura,Raymond U. Osarogiagbon,Harvey I. Pass,Marc de Perrot,Helmut Prosch,David C. Rice,Andreas Rimner,Enrico Ruffini,Shuji Sakai,Navneet Singh,Amy Stoll-D’Astice,Francisco Suárez,Ricardo Mingarini Terra,William D. Travis,Ming-Sound Tsao,Paula A. Ugalde,Shun-ichi Watanabe,Jacinta Wiens,Ignacio I. Wistuba,Yasushi Yatabe,Liyan Jiang,Kaoru Kubota,Eric Lim,Paul Martin Putora,Akif Turna,Pier Luigi Filosso,Kazuya Kondo,Dong Kwan Kim,Giuseppe Giaccone,Marco Lucchi,Eugene Blackwell,Thomas W. Rice,William D. Travis,Andrew G. Nicholson,M. Tsao,James D. Brierley,Jun Nakajima,Françoise Galateau,Bill Travis,Jim Mo Goo,Luis M. Montuenga,Hong Wei Wang,Katie Nishimura +102 more
TL;DR: The Staging and Prognostic Factors Committee of the IASLC is now issuing a call for participation in the next phase of the project, which is designed to inform the ninth edition of the TNM classification for lung cancer.
Journal ArticleDOI
Early-Stage NSCLC: Advances in Thoracic Oncology 2018
Raymond U. Osarogiagbon,Giulia Veronesi,Wentao Fang,Simon Ekman,Kenichi Suda,Joachim G.J.V. Aerts,Jessica S. Donington +6 more
TL;DR: An overview of the most recent body of work that moves us inexorably towards a world in which lung cancer is identified early, more patients undergo curative-intent treatment that achieves the promised cure, and those at risk for failure after treatment are identifiedEarly, when the cancer remains most vulnerable.
Journal ArticleDOI
Beyond Margin Status: Population-Based Validation of the Proposed International Association for the Study of Lung Cancer Residual Tumor Classification Recategorization.
Raymond U. Osarogiagbon,Nicholas Faris,Walter Stevens,Carrie Fehnel,Cheryl Houston-Harris,P. Ojeabulu,O. Akinbobola,Yu-Shen Lee,Meredith Ray,Matthew P. Smeltzer +9 more
TL;DR: The proposed R classification recategorization variables were mostly prognostic, except the highest mediastinal nodal station involvement, which suggested a dose-response relationship between nodal R-uncertainty and survival.
References
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The Will Rogers phenomenon. Stage migration and new diagnostic techniques as a source of misleading statistics for survival in cancer.
TL;DR: It is found that a cohort of patients with lung cancer first treated in 1977 had higher six-month survival rates for the total group and for subgroups in each of the three main TNM stages than a cohort treated between 1953 and 1964 at the same institutions.
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Lymph node mapping and curability at various levels of metastasis in resected lung cancer.
TL;DR: There was a significant difference for patients who had metastases to the subcrainal lymph nodes as compared to the prognosis for those who did not, and no significant difference in survival was detected between patients who were given adjuvant therapy and those who were not.
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Randomized trial of mediastinal lymph node sampling versus complete lymphadenectomy during pulmonary resection in the patient with N0 or N1 (less than hilar) non–small cell carcinoma: Results of the American College of Surgery Oncology Group Z0030 Trial
Gail Darling,Mark S. Allen,Paul A. Decker,Karla V. Ballman,Richard A. Malthaner,Richard Inculet,David R. Jones,Robert McKenna,Rodney J. Landreneau,Valerie W. Rusch,Joe B. Putnam +10 more
TL;DR: If systematic and thorough presection sampling of the mediastsinal and hilar lymph nodes is negative, mediastinal lymph node dissection does not improve survival in patients with early stage non-small cell lung cancer, but these results are not generalizable to patients staged radiographically or those with higher stage tumors.
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ESTS guidelines for intraoperative lymph node staging in non-small cell lung cancer
Didier Lardinois,Paul De Leyn,Paul Van Schil,Ramon Rami Porta,David A. Waller,Bernward Passlick,Marcin Zielinski,Klaus Junker,Erino Angelo Rendina,Hans-Beat Ris,Joachim Hasse,Frank Detterbeck,Toni Lerut,Walter Weder +13 more
TL;DR: The European Society of Thoracic Surgeons (ESTS) organized a workshop dealing with lymph node staging in non-small cell lung cancer (NSCLC), where the authors developed guidelines for definitions and the surgical procedures of intraoperative lymph nodes staging, and the pathologic evaluation of resected lymph nodes in patients with NSCLC.
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The International Association for the Study of Lung Cancer Lung Cancer Staging Project: Proposals for the Revision of the N Descriptors in the Forthcoming 8th Edition of the TNM Classification for Lung Cancer
Hisao Asamura,Kari Chansky,John Crowley,Peter Goldstraw,Valerie W. Rusch,Johan Vansteenkiste,Hirokazu Watanabe,Yi-Long Wu,Marcin Zieliński,David Ball,Ramón Rami-Porta +10 more
TL;DR: Current N descriptors adequately predict the prognosis and therefore should be maintained in the forthcoming staging system, and it is recommended that physicians record the number of metastatic lymph nodes and to further classify the N category using new descriptors, such as N1a, N1b, N2a,N2b, and N3, for further testing.