The impact of excision of ovarian endometrioma on ovarian reserve: a systematic review and meta-analysis.
TLDR
A negative impact of excision of endometriomas on ovarian reserve is suggested as evidenced by a significant postoperative fall in circulating AMH.Abstract:
Context: Endometriomas are mainly treated surgically. However, there has been concern over the potential damaging effect of this surgery on ovarian reserve. Objective: The aim of this meta-analysis was to investigate the impact of surgery for endometriomas on ovarian reserve as determined by serum anti-Mullerian hormone (AMH). Data Sources: MEDLINE, PubMed, and Embase were searched electronically. Study Selection: All prospective cohort studies that analyzed changes of serum AMH concentrations after surgical treatment of endometriomas were eligible. Twenty-one studies were identified, of which eight were selected for meta-analysis. Data Extraction: Two reviewers performed the data extraction independently. Data Synthesis: Pooled analysis of 237 patients showed a statistically significant decrease in serum AMH concentration after ovarian cystectomy (weighted mean difference −1.13 ng/ml; 95% confidence interval −0.37 to −1.88), although heterogeneity was high. Sensitivity analysis for studies with a preoper...read more
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Retrospective study: The diagnostic accuracy of conventional forceps biopsy of gastric epithelial compared to endoscopic submucosal dissection (STROBE compliant).
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Endometriosis: pathogenesis and treatment
TL;DR: Endometriosis is estrogen-dependent, manifests during reproductive years and is associated with pain and infertility, while lesion eradication is considered a fertility-enhancing procedure, the benefit on reproductive performance is moderate.
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The physiology and clinical utility of anti-Müllerian hormone in women
Didier Dewailly,Claus Yding Andersen,Adam H. Balen,Frank J. M. Broekmans,Nafi Dilaver,Renato Fanchin,Georg Griesinger,Tom Kelsey,Antonio La Marca,C.B. Lambalk,Helen D. Mason,Scott M. Nelson,Jenny A. Visser,W. Hamish B. Wallace,Richard A. Anderson +14 more
TL;DR: There is a linear relationship between AMH and oocyte yield after ovarian stimulation, which is of value in predicting ovarian hyperstimulation, and the submerged part of the iceberg of follicle growth, i.e. the intrinsic, so-called 'acyclic' ovarian activity is measured.
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Fertility Preservation in Women
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References
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Serum anti-mullerian hormone levels: a novel measure of ovarian reserve
I A J van Rooij,Frank J.M. Broekmans,E.R. te Velde,Bart C.J.M. Fauser,László F.J.M.M Bancsi,F. H. De Jong,Axel P. N. Themmen +6 more
TL;DR: Poor response in IVF, indicative of a diminished ovarian reserve, is associated with reduced baseline serum AMH concentrations, and it appears that AMH can be used as a marker for ovarian ageing.
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Antimüllerian hormone serum levels: a putative marker for ovarian aging.
TL;DR: Serum concentrations of antimüllerian hormone decreased over time in young normo-ovulatory women, whereas other markers associated with ovarian aging did not change, and concentration correlate with the number of antral follicles and age and less strongly with FSH level.
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Serum anti‐Müllerian hormone is more strongly related to ovarian follicular status than serum inhibin B, estradiol, FSH and LH on day 3
TL;DR: Serum AMH levels were more robustly correlated with the number of early antral follicles than inhibin B, E(2), FSH and LH on cycle day 3, suggesting that AMH may reflect ovarian follicular status better than the usual hormone markers.
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Serum antimüllerian hormone levels best reflect the reproductive decline with age in normal women with proven fertility: A longitudinal study
Ilse A.J. van Rooij,Frank J.M. Broekmans,G.J. Scheffer,Caspar W. N. Looman,J. Dik F. Habbema,Frank H. de Jong,Bart J.C.M. Fauser,Axel P. N. Themmen,Egbert R. te Velde +8 more
TL;DR: Serum AMH represents the best endocrine marker to assess the age-related decline of reproductive capacity, and shows the best consistency over time.
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The role of antimullerian hormone in prediction of outcome after IVF: comparison with the antral follicle count
TL;DR: It was shown that AMH has at least the same level of accuracy and clinical value for the prediction of poor response and nonpregnancy as AFC.