Journal ArticleDOI
The induction of diabetes in rats by intramuscular administration of streptozotocin.
A. Nakhoda,H. A. Wong +1 more
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Streptozotocin administered i.m. was as effective a diabetogenic agent as when administered iV, particularly for the induction of diabetes in small animals.Abstract:
Streptozotocin administered i.m. was as effective a diabetogenic agent as when administered i.v. This is useful, particularly for the induction of diabetes in small animals.read more
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Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia.
Isabel Matias,Marie-Paule Gonthier,Pierangelo Orlando,Vassilis Martiadis,Luciano De Petrocellis,Cristina Cervino,Stefania Petrosino,Laurence Hoareau,Franck Festy,Renato Pasquali,Régis Roche,Mario Maj,Uberto Pagotto,Palmiero Monteleone,Vincenzo Di Marzo +14 more
TL;DR: Peripheral endocannabinoid overactivity might explain why CB(1) blockers cause weight-loss independent reduction of lipogenesis, of hypoadiponectinemia, and of hyperinsulinemia in obese animals and humans.
Journal ArticleDOI
Insulin-secretagogue, antihyperlipidemic and other protective effects of gallic acid isolated from Terminalia bellerica Roxb. in streptozotocin-induced diabetic rats.
TL;DR: Findings indicate that gallic acid present in fruit rind of T. bellerica is the active principle responsible for the regeneration of β-cells and normalizing all the biochemical parameters related to the patho-biochemistry of diabetes mellitus and hence it could be used as a potent antidiabetic agent.
Journal ArticleDOI
Methanolic extract of African mistletoe (Viscum album) improves carbohydrate metabolism and hyperlipidemia in streptozotocin-induced diabetic rats.
Oluwatosin A. Adaramoye,Massoud Amanlou,Mehran Habibi-Rezaei,Parvin Pasalar,Moosavi-Movahedi Ali +4 more
TL;DR: In this article, the use of African mistletoe (AM) Viscum album (V. album ) in folkoric medicine to treat diabetes was presented, where the fasting blood glucose (FBG) levels of diabetic rats were monitored for 4 h.
Journal ArticleDOI
Antidiabetic effect of kolaviron, a biflavonoid complex isolated from Garcinia kola seeds, in Wistar rats.
TL;DR: KV offered significant antidiabetic and tissues protective effects in the rats, and attenuated the cardiac, renal and liver marker indices.
Journal ArticleDOI
Therapeutic potential of octyl gallate isolated from fruits of Terminalia bellerica in streptozotocin-induced diabetic rats.
R Cecily Rosemary Latha,P. Daisy +1 more
TL;DR: Findings indicate that Octyl gallate isolated first time from the fruit rind of T. bellerica has potential antidiabetic effect as it augments insulin secretion and normalizes the altered biochemical parameters in experimental diabetic rat models.
References
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Journal ArticleDOI
Immunoassay of insulin with insulin-antibody precipitate.
C.N. Hales,P.J. Randle +1 more
Journal ArticleDOI
Studies of the diabetogenic action of streptozotocin.
TL;DR: While the B-cytotoxic effects of streptozotocin resemble those of alloxan, their specificity is very much greater, as demonstrated by the wide margin between diabetogenic dose and general toxicity.
Journal ArticleDOI
Abnormal glucose tolerance in repeatedly bred rats with arteriosclerosis.
Journal ArticleDOI
Diabetic traits in a strain of rats1
Versa V. Cole,Ben K. Harned +1 more
TL;DR: Control glucose tolerance tests revealed that pedigreed, sexually mature, male Rats of the Yale strain2 exhibited a significantly lower glucose tolerance than rats of the Wistar strain of corresponding age and sex, grown under the same conditions and maintained on the same diet.
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