The induction of macrophage hemeoxygenase-1 is protective during acute kidney injury in aging mice
David A. Ferenbach,Noemie C.J. Nkejabega,Jennifer McKay,Abhijeet K. Choudhary,Madeleine A. Vernon,Matthew F. Beesley,Spike Clay,Bryan C. Conway,Lorna Marson,David C. Kluth,Jeremy Hughes +10 more
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TLDR
Failure of HO-1 induction following renal IRI worsens structural and functional injury in older mice and represents a therapeutic target in the elderly, Hence, HO- 1-positive renal macrophages mediate HA-induced protection in IRI.About:
This article is published in Kidney International.The article was published on 2011-05-01 and is currently open access. It has received 74 citations till now. The article focuses on the topics: Acute kidney injury & Acute tubular necrosis.read more
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Oxidative stress response and Nrf2 signaling in aging.
TL;DR: This review summarizes current studies on age-related impairment of Nrf2/EpRE function and discusses the changes in NRF2 regulatory mechanisms with aging.
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Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD
TL;DR: This Review explores the various mechanisms responsible for the initiation and propagation of acute kidney injury, the prototypic mechanisms by which a substantially damaged kidney can regenerate its normal architecture, and how the adaptive processes of repair can become maladaptive.
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Renal Aging: Causes and Consequences.
TL;DR: These features of the aged kidney are examined and the various validated and putative pathways contributing to the changes observed with aging in both experimental animal models and humans are explored.
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The Renal Mononuclear Phagocytic System
Peter J. Nelson,Andrew J. Rees,Matthew D. Griffin,Jeremy Hughes,Christian Kurts,Jeremy S. Duffield +5 more
TL;DR: Physical characteristics, ontogeny, and known functions of the main subsets of renal mononuclear phagocytes as they relate to homeostasis, surveillance against injury and infection, and immune-mediated inflammatory injury and repair within the kidney are described.
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Macrophages in Kidney Injury, Inflammation, and Fibrosis
Qi Cao,David Harris,Yiping Wang +2 more
TL;DR: The role of macrophages with different phenotypes in kidney injury, inflammation, and fibrosis in various acute and chronic kidney diseases is summarized.
References
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Acute Kidney Injury Increases Risk of ESRD among Elderly
Areef Ishani,Jay L. Xue,Jonathan Himmelfarb,Paul W. Eggers,Paul L. Kimmel,Paul L. Kimmel,Bruce A. Molitoris,Allan J. Collins +7 more
TL;DR: Elderly individuals with AKI, particularly those with previously diagnosed CKD, are at significantly increased risk for ESRD, suggesting that episodes of AKI may accelerate progression of renal disease.
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Incidence and Mortality of Acute Renal Failure in Medicare Beneficiaries, 1992 to 2001
Jay L. Xue,Frank Daniels,Robert A. Star,Paul L. Kimmel,Paul W. Eggers,Bruce A. Molitoris,Jonathan Himmelfarb,Allan J. Collins +7 more
TL;DR: The incidence rate of ARF in Medicare beneficiaries has been increasing and those of older age, male gender, and black race are more likely to have ARF, which is a major contributor to morbidity and mortality in hospitalized patients.
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Different faces of the heme-heme oxygenase system in inflammation
Frank A. D. T. G. Wagener,Hans-Dieter Volk,Dean Willis,Nader G. Abraham,Miguel P. Soares,Gosse J. Adema,Carl G. Figdor +6 more
TL;DR: Pre-induction of HO activity has been demonstrated to ameliorate inflammation and mediate potent resistance to oxidative injury and a better understanding of the complex heme-heme.
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Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis.
Neil C. Henderson,Alison C. MacKinnon,Sarah L. Farnworth,Tiina Kipari,Christopher Haslett,John P. Iredale,Fu-Tong Liu,Jeremy Hughes,Tariq Sethi +8 more
TL;DR: It is demonstrated for the first time that galectin-3 expression and secretion by macrophages is a major mechanism linking macrophage to the promotion of renal fibrosis.
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The role of heme oxygenase-1 promoter polymorphisms in human disease.
TL;DR: The present article systematically review the hitherto published evidence that promoter polymorphisms in the HO-1 gene exert functional importance by influencing the level ofHO-1 expression in different organ systems to suggest an important endogenous protective factor.