The Metabolic Syndrome and Male Infertility
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TLDR
A new MetS/male infertility paradigm is proposed and additional studies specifically addressing the components of MetS and their impact on male reproduction will enhance the understanding of the underlying pathophysiology.Abstract:
Metabolic syndrome (MetS) is highly prevalent, affecting more than 47 million US residents. This condition is also multifaceted, potentially leading to significant disturbance of numerous physiologic processes. This review article evaluates the literature regarding metabolic syndrome and male reproductive health. Links between obesity, dyslipidemia, hypertension, and insulin resistance are each examined with regard to their associated detrimental effects on male fertility. At the end of this manuscript, we propose a new MetS/male infertility paradigm. Additional studies specifically addressing the components of MetS and their impact on male reproduction will enhance our understanding of the underlying pathophysiology. These studies may also help clarify the role for therapeutic intervention.read more
Citations
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Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring
TL;DR: It is shown that paternal high-fat-diet (HFD) exposure programs β-cell ‘dysfunction’ in rat F1 female offspring induces increased body weight, adiposity, impaired glucose tolerance and insulin sensitivity, and the first report in mammals of non-genetic, intergenerational transmission of metabolic sequelae of a HFD from father to offspring.
Journal ArticleDOI
Ancestral dichlorodiphenyltrichloroethane (DDT) exposure promotes epigenetic transgenerational inheritance of obesity
Michael K. Skinner,Mohan Manikkam,Rebecca Tracey,Carlos Guerrero-Bosagna,Muksitul Haque,Eric E. Nilsson +5 more
TL;DR: Observations indicate ancestral exposure to DDT can promote obesity and associated disease transgenerationally, indicating the etiology of disease such as obesity may be in part due to environmentally induced epigenetic transgenerational inheritance.
Journal ArticleDOI
The effect of obesity on sperm disorders and male infertility.
TL;DR: The results of several studies point to an increased likelihood of abnormal semen parameters among overweight men, and an elevated risk for subfertility among couples in which the male partner is obese, associated with a higher incidence of male factor infertility.
Journal ArticleDOI
Impact of obesity on male fertility, sperm function and molecular composition.
TL;DR: This review will focus on how male obesity affects fertility and sperm quality with a focus on proposed mechanisms and the potential reversibility of these adverse effects.
Journal ArticleDOI
The complex interaction between obesity, metabolic syndrome and reproductive axis: a narrative review.
Konstantinos Michalakis,Gesthimani Mintziori,Athina Kaprara,Basil C. Tarlatzis,Dimitrios G. Goulis +4 more
TL;DR: An indirect evidence for the interplay between MS and reproductive axis is the fact that when treating components of one, parameters of the other can be improved as well, and therapeutic interventions include lifestyle modifications, pharmacological agents, such as sex hormone replacement therapy, and surgical procedures.
References
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Prevalence of the Metabolic Syndrome Among US Adults: Findings From the Third National Health and Nutrition Examination Survey
TL;DR: These results from a representative sample of US adults show that the metabolic syndrome is highly prevalent and the large numbers of US residents with the metabolic Syndrome may have important implications for the health care sector.
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Metabolic Syndrome A Comprehensive Perspective Based on Interactions Between Obesity, Diabetes, and Inflammation
TL;DR: The original conceptualization of this syndrome was on the basis of resistance to the metabolic actions of insulin, and it was maintained that hyperinsulinemia itself contributes to atherogenicity, and thus, insulin is atherogenic, leading to the coronary heart disease and cerebrovascular disease associated with this syndrome.
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Incidence of erectile dysfunction in men 40 to 69 years old: longitudinal results from the massachusetts male aging study
Catherine B. Johannes,Andre B. Araujo,Henry A. Feldman,Carol A. Derby,Ken Kleinman,John B. McKinlay +5 more
TL;DR: The incidence of erectile dysfunction in men 40 to 69 years old in Massachusetts was estimated during an average 8.8-year followup, and how risk varied with age, socioeconomic status and medical conditions was determined.
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Epidemiology of erectile dysfunction: results of the 'Cologne Male Survey'
TL;DR: It is concluded that regular sexual activity is a normal finding in advanced age, and general non-reimbursability of treatment for ED appears to be unacceptable.
Journal ArticleDOI
Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin.
TL;DR: It is concluded that insulin and PRL inhibit SHBG production and confirmed that T4, T, and E2 stimulate SH BG production in vitro, suggesting that insulin or PRL may be important factors in the regulation of SHBGProduction in vivo.