The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysis.
TLDR
This systematic review with meta-analysis has not found evidence of an association between increased BMI and semen parameters, and there was strong evidence of a negative relationship for testosterone, SHBG and free testosterone with increased BMI.Abstract:
Background It has been suggested that body mass index (BMI), especially obesity, is associated with subfertility in men. Semen parameters are central to male fertility and reproductive hormones also play a role in spermatogenesis. This review aimed to investigate the association of BMI with semen parameters and reproductive hormones in men of reproductive age. Methods MEDLINE, EMBASE, Biological Abstracts, PsycINFO and CINAHL databases and references from relevant articles were searched in January and February 2009. Outcomes included for semen parameters were sperm concentration, total sperm count, semen volume, motility and morphology. Reproductive hormones included were testosterone, free testosterone, estradiol, FSH, LH, inhibin B and sex hormone binding globulin (SHBG). A meta-analysis was conducted to investigate sperm concentration and total sperm count. Results In total, 31 studies were included. Five studies were suitable for pooling and the meta-analysis found no evidence for a relationship between BMI and sperm concentration or total sperm count. Overall review of all studies similarly revealed little evidence for a relationship with semen parameters and increased BMI. There was strong evidence of a negative relationship for testosterone, SHBG and free testosterone with increased BMI. Conclusions This systematic review with meta-analysis has not found evidence of an association between increased BMI and semen parameters. The main limitation of this review is that data from most studies could not be aggregated for meta-analysis. Population-based studies with larger sample sizes and longitudinal studies are required.read more
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Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content
Tod Fullston,E. Maria C. Ohlsson Teague,Nicole O. Palmer,Miles J. DeBlasio,Megan Mitchell,Mark A. Corbett,Cristin G. Print,Julie A. Owens,Michelle Lane +8 more
TL;DR: Diet‐induced paternal obesity modulates sperm microRNA content and germ cell methylation status, which are potential signals that program offspring health and initiate the transmission of obesity and impaired metabolic health to future generations.
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BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis
Nathalie Sermondade,Céline Faure,Léopold Fezeu,A G Shayeb,Jens Peter Bonde,Tina Kold Jensen,M. van Wely,Jan Tan Cao,A. C. Martini,M Eskandar,Jorge E. Chavarro,Jorge E. Chavarro,S Koloszar,John M. Twigt,Cecilia Høst Ramlau-Hansen,Edson Borges,Francesco Lotti,Régine P.M. Steegers-Theunissen,B Zorn,Alex J. Polotsky,S. La Vignera,Brenda Eskenazi,Kelton Tremellen,E V Magnusdottir,I Fejes,Serge Hercberg,Rachel Levy,Sébastien Czernichow +27 more
TL;DR: Overweight and obesity were associated with an increased prevalence of azoospermia or oligozoospermia, and whether weight normalization could improve sperm parameters should be evaluated further.
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Low Testosterone Associated With Obesity and the Metabolic Syndrome Contributes to Sexual Dysfunction and Cardiovascular Disease Risk in Men With Type 2 Diabetes
Christina Wang,Graham Jackson,T. Hugh Jones,Alvin M. Matsumoto,Ajay Nehra,Michael A. Perelman,Ronald S. Swerdloff,Abdul Traish,Michael Zitzmann,Glenn R. Cunningham +9 more
TL;DR: This review focuses on the multidirectional impact of low testosterone associated with obesity and the metabolic syndrome and its effects on erectile dysfunction and CVD risk in men with type 2 diabetes.
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Impact of obesity on male fertility, sperm function and molecular composition.
TL;DR: This review will focus on how male obesity affects fertility and sperm quality with a focus on proposed mechanisms and the potential reversibility of these adverse effects.
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The diagnosis of male infertility: an analysis of the evidence to support the development of global WHO guidance—challenges and future research opportunities
Christopher L.R. Barratt,Lars Björndahl,Christopher J. De Jonge,Dolores J. Lamb,Francisco Osorio Martini,Robert I McLachlan,Robert D. Oates,Sheryl van der Poel,Sheryl van der Poel,Bianca St John,Mark Sigman,Rebecca Z. Sokol,Herman Tournaye +12 more
TL;DR: The consensus guideline methodology is described, the evidence-based recommendations provided to the World Health Organization for their consideration in the development of global guidance are summarized and a narrative review of the diagnosis of male infertility as related to the eight prioritized PICO questions is presented.
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