Journal ArticleDOI
The natural compounds piperovatine and piperlonguminine induce autophagic cell death on Trypanosoma cruzi.
P. Veiga-Santos,Vânia Cristina Desoti,Nathielle Miranda,Tânia Ueda-Nakamura,Benedito Prado Dias-Filho,Sueli de Oliveira Silva,Diógenes Aparício Garcia Cortez,João Carlos Palazzo de Mello,Celso Vataru Nakamura +8 more
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TLDR
The antitrypanosomal activity of the amides piperovatine and piperlonguminine isolated from Piper ovatum against epimastigotes and intracellular amastigote forms of T. cruzi is demonstrated and evidence a possible autophagic process is evidence.About:
This article is published in Acta Tropica.The article was published on 2013-03-01. It has received 24 citations till now. The article focuses on the topics: Piperlonguminine & Trypanosoma cruzi.read more
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Piperlongumine induces apoptotic and autophagic death of the primary myeloid leukemia cells from patients via activation of ROS-p38/JNK pathways
TL;DR: Piperlongumine induces apoptotic and autophagic death of the primary myeloid leukemia cells from patients via activation of ROS-p38/JNK pathways.
Journal ArticleDOI
Evaluation of Chemical Composition and Antileishmanial and Antituberculosis Activities of Essential Oils of Piper Species
Karine Zanoli Bernuci,Camila Cristina Iwanaga,Fernadez-Andrade Cm,Fabiana Brusco Lorenzetti,Eduardo Caio Torres-Santos,Viviane dos Santos Faiões,José Eduardo Gonçalves,do Amaral W,Deschamps C,Regiane Bertin de Lima Scodro,R. F. Cardoso,Vanessa Pietrowski Baldin,D. A. G. Cortez +12 more
TL;DR: The cytotoxicity of the essential oils was evaluated in peritoneal macrophages and the oils of P. diospyrifolium and P. aduncum and suggests their potential for therapeutic purposes.
Journal ArticleDOI
Activities of Psilostachyin A and Cynaropicrin against Trypanosoma cruzi In Vitro and In Vivo
Cristiane França da Silva,Denise da Gama Jaen Batista,Julianna Siciliano de Araújo,Marcos Meuser Batista,Jessica Lionel,Elen Mello de Souza,Erica Ripoll Hammer,Patrícia Bernardino da Silva,Maria De Mieri,Michael Adams,Stefanie Zimmermann,Stefanie Zimmermann,Matthias Hamburger,Reto Brun,Wolfgang Schühly,Maria de Nazaré Correia Soeiro +15 more
TL;DR: The data demonstrate that although it is very promising against African trypanosomes, cynaropicrin does not show efficacy compared to benznidazole in acute mouse models of T. cruzi infection.
Journal ArticleDOI
Natural sesquiterpene lactones induce programmed cell death in Trypanosoma cruzi: a new therapeutic target?
Veronica Jimenez,Ulrike Kemmerling,Rodolfo Paredes,Juan Diego Maya,Miguel A. Sosa,N. Galanti,N. Galanti +6 more
TL;DR: DhL and Hln induce programmed cell death in T. cruzi replicative epimastigote and infective trypomastigotes forms, which is a different mechanism of action than the conventional drugs to kill the parasite.
Journal ArticleDOI
Autophagy: A necessary process during the Trypanosoma cruzi life-cycle.
TL;DR: This review describes the latest findings concerning the participation of autophagy in both the T. cruzi differentiation processes and during the interaction of parasites within the host cells.
References
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Journal Article
Growth and differentiation in trypanosoma cruzi. i. origin of metacyclic trypanosomes in liquid media.
Journal ArticleDOI
The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes
E. F. C. Blommaart,Ulrike Krause,Jacques P. M. Schellens,Heleen Vreeling-Sindelárová,Alfred J. Meijer +4 more
TL;DR: 3-Methyladenine, which is commonly used as a specific inhibitor of autophagic sequestration, was an inhibitor of phosphatidylinositol 3-kinase, thus providing a target for its action.
Journal Article
Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles.
TL;DR: It is demonstrated, after subcellular fractionation procedures, that MDC-labeled organelles contained the lysosomal enzymes acid phosphatase and the mature form of cathepsin D, and Membrane markers of rough endoplasmic reticulum (TRAM and sec61 beta), and for smooth endoplasmsic reticle (cytochrome P450) were not detected in the same fractions.