The neurobiology of aggression and violence.
Daniel R. Rosell,Larry J. Siever +1 more
TLDR
The construct of aggression is introduced, with a focus on issues related to its heterogeneity, as well as the importance of refining the aggression phenotype in order to reduce pathophysiologic variability, and areas of focus are suggested for future directions in the field.Abstract:
Aggression and violence represent a significant public health concern and a clinical challenge for the mental healthcare provider. A great deal has been revealed regarding the neurobiology of violence and aggression, and an integration of this body of knowledge will ultimately serve to advance clinical diagnostics and therapeutic interventions. We will review here the latest findings regarding the neurobiology of aggression and violence. First, we will introduce the construct of aggression, with a focus on issues related to its heterogeneity, as well as the importance of refining the aggression phenotype in order to reduce pathophysiologic variability. Next we will examine the neuroanatomy of aggression and violence, focusing on regional volumes, functional studies, and interregional connectivity. Significant emphasis will be on the amygdala, as well as amygdala-frontal circuitry. Then we will turn our attention to the neurochemistry and molecular genetics of aggression and violence, examining the extensive findings on the serotonergic system, as well as the growing literature on the dopaminergic and vasopressinergic systems. We will also address the contribution of steroid hormones, namely, cortisol and testosterone. Finally, we will summarize these findings with a focus on reconciling inconsistencies and potential clinical implications; and, then we will suggest areas of focus for future directions in the field.read more
Citations
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Deep Brain Stimulation for the Treatment of Aggressive Behaviour: Considerations on Pathophysiology and Target Choice.
TL;DR: The observed observations on the pathogenesis of IED led us to consider the disease as a circuitopathy or a system disease, in which the mesolimbic “reward” system has a central role, and the possible structure connecting the 2 above-mentioned DBS target regions.
Journal ArticleDOI
Two types of aggression in human evolution.
TL;DR: The bimodal classification of human aggression helps solve two important puzzles, including the execution paradox, concerned with the hypothesized effects of capital punishment on self-domestication in the Pleistocene.
Journal ArticleDOI
Systematic meta-analyses and field synopsis of genetic association studies of violence and aggression
TL;DR: Current evidence does not support the use of such genes to predict dangerousness or as markers for therapeutic interventions, and no association between any polymorphism analyzed and aggression is found.
Journal ArticleDOI
Epilepsy, Antiepileptic Drugs, and Aggression: An Evidence-Based Review
Martin J. Brodie,Frank M.C. Besag,Frank M.C. Besag,Alan B. Ettinger,Marco Mula,Marco Mula,Gabriella Gobbi,Stefano Comai,Stefano Comai,Albert P. Aldenkamp,Bernhard J. Steinhoff +10 more
TL;DR: An evidence-based summary of available data surrounding aggression-related behaviors with each of the currently available AEDs in both adults and in children/adolescents with epilepsy is presented.
Федеральное государственное бюджетное учреждение «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний» Сибирского отделения Российской академии медицинских наук, Кемерово, Россия
E. N. Usoltseva,Federal State +1 more
TL;DR: In this article, the authors proposed a method to improve the quality of the information provided by the user by using the information from the user's profile and the user profile of the service provider.
References
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Social Information‐Processing Mechanisms in Reactive and Proactive Aggression
Nicki R. Crick,Kenneth A. Dodge +1 more
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