Journal ArticleDOI
The neurobiology of depression and antidepressant action
TLDR
It is suggested that the problem of depression comprises three sub-problems: first episodes in people with low vulnerability ('simple' depressions); an increase in vulnerability and autonomy from stress that develops over episodes of depression (kindling); and factors that confer vulnerability to a first episode (a depressive diathesis).About:
This article is published in Neuroscience & Biobehavioral Reviews.The article was published on 2013-12-01. It has received 421 citations till now. The article focuses on the topics: First episode.read more
Citations
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The chronic mild stress (CMS) model of depression: History, evaluation and usage
TL;DR: An update on the validity and reliability of the CMS model, and recent data on the neurobiological basis of CMS effects and the mechanisms of antidepressant action are reviewed: the volume of this research may be unique in providing a comprehensive account of antidepressants action within a single model.
Journal ArticleDOI
When Not Enough Is Too Much: The Role of Insufficient Glucocorticoid Signaling in the Pathophysiology of Stress-Related Disorders
TL;DR: Neuroendocrine data provide evidence of insufficient glucocorticoid signaling in stress-related neuropsychiatric disorders, including posttraumatic stress disorder and major depression, which are associated with immune system activation/inflammation, high SNS tone, and CRH hypersecretion.
Journal ArticleDOI
VEGF Links Hippocampal Activity with Neurogenesis, Learning, and Memory
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Physical activity and depression: Towards understanding the antidepressant mechanisms of physical activity.
TL;DR: This review comprehensively assess key biological and psychosocial mechanisms through which physical activity exerts antidepressant effects, with a particular focus on exercise.
Journal ArticleDOI
The Rodent Forced Swim Test Measures Stress-Coping Strategy, Not Depression-like Behavior.
TL;DR: Evidence is reviewed that argues a more thoughtful consideration of the FST, and more precise terminology, would benefit the study of stress and disorders characterized by altered response to stress, which include but are not limited to depression.
References
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Journal ArticleDOI
A Neural Substrate of Prediction and Reward
TL;DR: Findings in this work indicate that dopaminergic neurons in the primate whose fluctuating output apparently signals changes or errors in the predictions of future salient and rewarding events can be understood through quantitative theories of adaptive optimizing control.
Journal ArticleDOI
Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
Avshalom Caspi,Karen Sugden,Terrie E. Moffitt,Alan Taylor,Ian W. Craig,Hona Lee Harrington,Joseph L. McClay,Jonathan Mill,Judy Martin,Antony W. Braithwaite,Richie Poulton +10 more
TL;DR: Evidence of a gene-by-environment interaction is provided, in which an individual's response to environmental insults is moderated by his or her genetic makeup.
Journal ArticleDOI
Neurogenesis in the adult human hippocampus
Peter S. Eriksson,Ekaterina Perfilieva,Thomas Björk-Eriksson,Ann Marie Alborn,Claes Nordborg,Daniel A. Peterson,Fred H. Gage +6 more
TL;DR: It is demonstrated that new neurons, as defined by these markers, are generated from dividing progenitor cells in the dentate gyrus of adult humans, indicating that the human hippocampus retains its ability to generate neurons throughout life.
Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.