Journal ArticleDOI
The pineal hormone melatonin exaggerates development of collagen-induced arthritis in mice
TLDR
The hypothesis that the pineal gland can exaggerate the development of CIA via a high release of melatonin, probably via enhancement of T-cell priming is supported.About:
This article is published in Journal of Neuroimmunology.The article was published on 1992-07-01. It has received 77 citations till now. The article focuses on the topics: Melatonin & Pineal gland.read more
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Melatonin: buffering the immune system.
Antonio Carrillo-Vico,Patricia J. Lardone,Nuria Álvarez-Sánchez,Ana Rodríguez-Rodríguez,Juan M. Guerrero +4 more
TL;DR: The data reviewed in this paper support the idea of melatonin as an immune buffer, acting as a stimulant under basal or immunosuppressive conditions or as an anti-inflammatory compound in the presence of exacerbated immune responses, such as acute inflammation.
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The immunoneuroendocrine role of melatonin
TL;DR: The pineal gland might be viewed as the crux of a sophisticated immunoneuroendocrine network which functions as an unconscious, diffuse sensory organ that is particularly apparent in immunodepressive states.
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Melatonin: From Basic Research to Cancer Treatment Clinics
TL;DR: The evidence regarding the potential use of melatonin in cancer treatment is summarized and rationale for the design of larger translational research-based clinical trials is provided.
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Regional variation in multiple sclerosis prevalence in Australia and its association with ambient ultraviolet radiation.
TL;DR: It is demonstrated that the regional variation in MS prevalence in the continent of Australia could be closely predicted by regional UVR levels, consistent with the hypothesis that UVR exposure may reduce the risk of MS possibly via T-lymphocyte-mediated immunosuppression.
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The immunotherapeutic potential of melatonin.
TL;DR: MEL may be used to stimulate the immune response during viral and bacterial infections as well as to strengthen the immune reactivity as a prophylactic procedure in both mice and cancer patients, and the haemopoietic effect of MEL may diminish the toxicity associated with common chemotherapeutic protocols.
References
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Journal ArticleDOI
Isolation of melatonin, the pineal gland factor that lightens melanocytes1
Journal Article
Effects of the pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture.
Steven M. Hill,David E. Blask +1 more
TL;DR: The hypothesis that melatonin, at physiological concentrations, exerts a direct but reversible, antiproliferative effect on MCF-7 cell growth in culture support the hypothesis that this indoleamine has the potential to inhibit breast cancer growth by directly inhibiting cell proliferation.
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Role of the pineal gland in immunity. Circadian synthesis and release of melatonin modulates the antibody response and antagonizes the immunosuppressive effect of corticosterone.
TL;DR: The results suggest that the pineal gland has important immunomodulatory functions through its cyclic, circadian release of MEL, and MEL administration was able to antagonize the depression of antibody production induced by corticosterone in vivo.
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Nature of the collagen synthesized by a transplanted chondrosarcoma.
TL;DR: A chondrosarcoma grown in rats was found to produce a single kind of collagen, which was identified as a type II collagen, the cartilage specific protein.