Melatonin: buffering the immune system.
Antonio Carrillo-Vico,Patricia J. Lardone,Nuria Álvarez-Sánchez,Ana Rodríguez-Rodríguez,Juan M. Guerrero +4 more
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TLDR
The data reviewed in this paper support the idea of melatonin as an immune buffer, acting as a stimulant under basal or immunosuppressive conditions or as an anti-inflammatory compound in the presence of exacerbated immune responses, such as acute inflammation.Abstract:
Melatonin modulates a wide range of physiological functions with pleiotropic effects on the immune system. Despite the large number of reports implicating melatonin as an immunomodulatory compound, it still remains unclear how melatonin regulates immunity. While some authors argue that melatonin is an immunostimulant, many studies have also described anti-inflammatory properties. The data reviewed in this paper support the idea of melatonin as an immune buffer, acting as a stimulant under basal or immunosuppressive conditions or as an anti-inflammatory compound in the presence of exacerbated immune responses, such as acute inflammation. The clinical relevance of the multiple functions of melatonin under different immune conditions, such as infection, autoimmunity, vaccination and immunosenescence, is also reviewed.read more
Citations
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Melatonin as an antioxidant: under promises but over delivers.
Russel J. Reiter,Juan C. Mayo,Dun Xian Tan,Rosa M. Sainz,Moisés Alejandro Alatorre-Jiménez,Lilian Qin +5 more
TL;DR: It is the current feeling of the authors that, in view of the widely diverse beneficial functions that have been reported for melatonin, these may be merely epiphenomena of the more fundamental, yet‐to‐be identified basic action(s) of this ancient molecule.
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Functions of melatonin in plants: a review
TL;DR: The multiple changes in gene expression caused by melatonin point to its role as a multiregulatory molecule capable of coordinating many aspects of plant development, suggesting that melatonin is an excellent prospect for crop improvement.
Journal ArticleDOI
Melatonin: plant growth regulator and/or biostimulator during stress?
TL;DR: Recent data on the gene-regulation capacity of melatonin point to many interesting features, such as the upregulation of anti-stress genes and recent aspects of the auxin-independent effects ofmelatonin as a plant growth regulator, which makes melatonin an interesting candidate for use as a natural biostimulating treatment for field crops.
Journal ArticleDOI
Association between light at night, melatonin secretion, sleep deprivation, and the internal clock: Health impacts and mechanisms of circadian disruption.
TL;DR: Countermeasures to the effects of ALAN, such as melatonin, bright light, or psychotropic drugs, have been proposed as a means to combat circadian clock disruption and improve adaptation to shift and night work.
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The role of melatonin in the cells of the innate immunity: a review
TL;DR: The effects and action mechanisms of melatonin in the different cells that belong to or participate in the innate immunity, such as monocytes–macrophages, dendritic cells, neutrophils, eosinophils, mast cells, and natural killer cells are summarized.
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