Journal ArticleDOI
The prevalence of pain in multiple sclerosis: A multicenter cross-sectional study
Claudio Solaro,Giampaolo Brichetto,Maria Pia Amato,Eleonora Cocco,Bruno Colombo,G. D’Aleo,Claudio Gasperini,Angelo Ghezzi,Vittorio Martinelli,Clara Milanese,Francesco Patti,Maria Trojano,E. Verdun,G. L. Mancardi +13 more
TLDR
Comparison between different groups showed significant differences for age, Expanded Disability Status Scale, disease duration, and disease course, but not for sex, underlines the relevance of pain in the clinical history of MS.Abstract:
In a multicenter cross-sectional study, the authors assessed pain in patients with multiple sclerosis (MS) using a symptom-oriented approach. Out of 2,077 questionnaires, we used 1,672 for data analysis. Pain and frequencies included trigeminal neuralgia 2%, Lhermitte's sign 9%, dysesthetic pain 18.1%, back pain 16.4%, and painful tonic spasms 11%. Comparison between different groups showed significant differences for age, Expanded Disability Status Scale, disease duration, and disease course, but not for sex. This study underlines the relevance of pain in the clinical history of MS.read more
Citations
More filters
Journal ArticleDOI
Neuroinflammation and the generation of neuropathic pain
A Ellis,David L.H. Bennett +1 more
TL;DR: This review aims to provide an overview of inflammatory mechanisms at differing levels of the sensory neuroaxis with a focus on neuropathic pain and to compare and contrast neuropathicPain states such as traumatic nerve injury which is associated with a vigorous inflammatory response and chemotherapy induced pain in which the inflammatory response is much more modest.
Journal ArticleDOI
Pain associated with multiple sclerosis: Systematic review and proposed classification
TL;DR: A systematic review of the literature describing pain in MS patients spans four decades and has employed a range of different methodologies to summarize current understanding of the association between MS and pain to provide a basis for the design and interpretation of future studies.
Journal ArticleDOI
The role of the immune system in the generation of neuropathic pain.
TL;DR: An important challenge for the future is to establish to what extent this immune response initiates or maintains neuropathic pain in patients and thus whether it is amenable to therapy.
Journal ArticleDOI
Natural history of multiple sclerosis symptoms.
TL;DR: This work calculates symptom prevalence in each of the 11 domains of multiple sclerosis for years 0 to 30 from symptom onset and demonstrates that a majority of participants perceive at least some degree of impairment in most domains as early as the first year of disease.
Journal ArticleDOI
Persistent pain and uncomfortable sensations in persons with multiple sclerosis.
TL;DR: The results indicate that the high prevalence of MS‐related severe pain, low satisfaction with management of intense pain, and the perceived interference with quality of life indicators necessitate greater attention by healthcare providers to the management of pain and uncomfortable sensations in the MS population.
References
More filters
Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
Pain prevalence, severity and impact in a clinic sample of multiple sclerosis patients
Catherine J. Archibald,Patrick J. McGrath,Patrick J. McGrath,Paul Ritvo,Paul Ritvo,John D. Fisk,Virender Bhan,Charles Maxner,Thomas J. Murray +8 more
TL;DR: There was wide variability in the number of pain hours/week reported with 17.6% of the sample reporting continuous pain for the month preceding assessment, and patients with pain reported poorer mental health and more social‐role handicap.
Journal ArticleDOI
Pain syndromes in multiple sclerosis
TL;DR: MS patients with pain were similar to the pain-free group in mean age of onset, average duration of disease, spinal cord involvement, and mean rating on Kurtzke Disability Status Scale, but differed in sex ratio with a higher female-to-male ratio in the pain group.
Journal ArticleDOI
Pain in patients with multiple sclerosis: a population-based study.
Kristina Bacher Svendsen,Troels S. Jensen,Kim Overvad,H. J. Hansen,Nils Koch-Henriksen,Flemming W. Bach +5 more
TL;DR: The frequency of reported pain in MS patients was not higher than in the background population, however, pain intensity, the need for analgesic treatment, and the impact of pain on daily life were higher in sclerosis patients.
Journal ArticleDOI
Acute and chronic pain syndromes in multiple sclerosis.
TL;DR: The number of patients with pain at the time of the examination increased with age and duration of disease, and Patients with pain were significantly more often spastic and significantly moreoften sought alternative treatment forms.