Journal ArticleDOI
The prevalence of radiographic vertebral fractures in Latin American countries: the Latin American Vertebral Osteoporosis Study (LAVOS)
Patricia Clark,Fidencio Cons-Molina,Margarita Deleze,S. Ragi,Lillian Haddock,Jose R. Zanchetta,J. J. Jaller,L. Palermo,Juan O Talavera,D. O. Messina,J. Morales-Torres,Jorge Salmerón,A. Navarrete,Erick Suárez,Cynthia M. Pérez,Steve Cummings +15 more
Reads0
Chats0
TLDR
It is concluded that radiographically ascertained vertebra fractures are common in Latin America and health authorities in the region should be aware and consider implementing measures to prevent vertebral fractures.Abstract:
In the first population-based study of vertebral fractures in Latin America, we found a 11.18 (95% CI 9.23–13.4) prevalence of radiographically ascertained vertebral fractures in a random sample of 1,922 women from cities within five different countries. These figures are similar to findings from studies in Beijing, China, some regions of Europe, and slightly lower than those found in the USA using the same standardized methodology. We report the first study of radiographic vertebral fractures in Latin America. An age-stratified random sample of 1,922 women aged 50 years and older from Argentina, Brazil, Colombia, Mexico, and Puerto Rico were included. In all cases a standardized questionnaire and lateral X-rays of the lumbar and thoracic spine were obtained after informed consent. A standardized prevalence of 11.18 (95% CI 9.23–13.4) was found. The prevalence was similar in all five countries, increasing from 6.9% (95% CI 4.6–9.1) in women aged 50–59 years to 27.8% (95% CI 23.1–32.4) in those 80 years and older (p for trend < 0.001). Among different risk factors, self-reported height loss OR = 1.63 (95% CI: 1.18–2.25), and previous history of fracture OR = 1.52 (95% CI: 1.14–2.03) were significantly (p < 0.003 and p < 0.04 respectably) associated with the presence of radiographic vertebral fractures in the multivariate analysis. In the bivariate analyses HRT was associated with a 35% lower risk OR = 0.65 (95% CI: 0.46–0.93) and physical activity with a 27% lower risk of having a vertebral fracture OR = 0.73 (95% CI: 0.55–0.98), but were not statistically significant in multivariate analyses We conclude that radiographically ascertained vertebral fractures are common in Latin America. Health authorities in the region should be aware and consider implementing measures to prevent vertebral fractures.read more
Citations
More filters
Journal ArticleDOI
Worldwide prevalence and incidence of osteoporotic vertebral fractures
TL;DR: Worldwide, the variation in vertebral fractures is lower than observed for hip fractures, and some of the highest rates are from North America and unexpectedly Asia.
Journal ArticleDOI
Geographic and ethnic disparities in osteoporotic fractures.
TL;DR: Improvements in fracture assessment, in particular for nonhip fractures, and identification of factors that contribute to this variability might substantially influence the understanding of osteoporotic fracture aetiology and provide new avenues for prevention.
Journal ArticleDOI
Vertebral Fractures: Clinical Importance and Management
David L. Kendler,Douglas C. Bauer,K. S. Davison,Larry Dian,David A. Hanley,S. T. Harris,Michael R. McClung,Paul D. Miller,John T. Schousboe,Chui K. Yuen,E. M. Lewiecki +10 more
TL;DR: Radiology reports of vertebral fracture need to clearly state that the patient has a "fracture," with further pertinent details such as the number, recency, and severity, each of which is associated with risk of future fractures.
Journal ArticleDOI
Defining ethnic and racial differences in osteoporosis and fragility fractures.
TL;DR: Across ethnic and racial groups, more women experience fractures than the combined number of women who experience breast cancer, myocardial infarction, and coronary death in 1 year.
Journal ArticleDOI
Increased serum sclerostin and decreased serum IGF-1 are associated with vertebral fractures among postmenopausal women with type-2 diabetes
Mohammed-Salleh M. Ardawi,Daad H. Akhbar,A.A. AlShaikh,Maimoona Ahmed,Mohammed H. Qari,Abdulrahim A. Rouzi,Ahmed Y. Ali,Adel A. Abdulrafee,Mamdouh Y. Saeda +8 more
TL;DR: Increased serum sclerostin and decreased s-IGF-1 were associated with VFs among postmenopausal women with T2DM, suggesting that sclerOSTin and/or IGF-1 may be involved in increased bone fragility in T2 DM and could be potential markers of VF severity.
References
More filters
Journal ArticleDOI
Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group.
Steven R. Cummings,Michael C. Nevitt,Warren S. Browner,Katie L. Stone,Kathleen M. Fox,Kristine E. Ensrud,Jane A. Cauley,Dennis Black,Thomas M. Vogt +8 more
TL;DR: Women with multiple risk factors and low bone density have an especially high risk of hip fracture and maintaining body weight, walking for exercise, avoiding long-acting benzodiazepines, minimizing caffeine intake, and treating impaired visual function are among the steps that may decrease the risk.
Journal ArticleDOI
Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio
TL;DR: Cox or Poisson regression with robust variance and log-binomial regression provide correct estimates and are a better alternative for the analysis of cross-sectional studies with binary outcomes than logistic regression, since the prevalence ratio is more interpretable and easier to communicate to non-specialists than the odds ratio.
Journal ArticleDOI
Epidemiology and outcomes of osteoporotic fractures.
TL;DR: In this paper, epidemiological research was done and used to identify individuals at high risk of disabling fractures, thereby allowing careful allocation of expensive treatments to individuals most in need, which could potentially be as expensive as medical treatment of fractures.
Assessment of fracture risk and its application to screening for postmenopausal osteoporos
L. Alexeeva,P. Burkhardt,C. Christiansen,C. Cooper,P. Delmas,O. Johnell,C. Johnston,J. Kanis,P. Lips,Lee J. Melton,P. Meunier,Ego Seeman,J. Stepan,A. Tosteson,N. Khaltaev,J. P. Bonjour,H. Gong-Yi,R. Lindsay +17 more
TL;DR: There is little evidence that osteoporosis can usefully be tackled by a public health policy to influence risk factors such as smoking, exercise and nutrition, so the selective use of screening techniques will improve the cost-benefit ratio of intervention.
Related Papers (5)
An estimate of the worldwide prevalence and disability associated with osteoporotic fractures.
Olof Johnell,John A. Kanis +1 more