The proliferation marker thymidine kinase 1 in clinical use (Review)
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TLDR
Thymidine kinase 1 (TK1), a cell cycle-dependent and thus a proliferation-related marker, has been extensively studied during the last decades and is an emerging potential proliferating biomarker in oncology that may be used for the prognosis and monitoring of tumor therapy, relapse and survival.Abstract:
Tumor-related biomarkers are used for the diagnosis, prognosis and monitoring of treatments and follow-up of cancer patients, although only a few are fully accepted for the detection of invisible/visible tumors in health screening. Thymidine kinase 1 (TK1), a cell cycle-dependent and thus a proliferation-related marker, has been extensively studied during the last decades, using both biochemical and immunological techniques. Therefore, TK1 is an emerging potential proliferating biomarker in oncology that may be used for the prognosis and monitoring of tumor therapy, relapse and survival. In addition, TK1 concentration in serum (STK1p) is a useful biomarker in healthy screening for the detection of potential malignancy development as well as the identification of early-stage tumors, with a few false-positive cases (ROC value, 0.96; tumor proliferation sensitivity, 0.80; specificity, 0.99). In this review, we examine results regarding the expression of STK1p and TK1 in relation to cancer patients and STK1p in health screening published between 2000 and 2012. The use of tumor-related markers recommended by international cancer organizations is also discussed. This review provides valuable information for applications in tumor patients, in health screening and for cancer research.read more
Citations
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Identification of hub genes in prostate cancer using robust rank aggregation and weighted gene co-expression network analysis
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Overexpression of thymidylate synthase (TYMS) is associated with aggressive tumor features and early PSA recurrence in prostate cancer.
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Thymidine kinase 1 through the ages: a comprehensive review.
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Dynamic changes in intron retention are tightly associated with regulation of splicing factors and proliferative activity during B-cell development
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References
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Regulation and Functional Contribution of Thymidine Kinase 1 in Repair of DNA Damage
TL;DR: The data suggest that more dTTP synthesis via TK1 take place after genotoxic insults in tumor cells, improving DNA repair during G2 arrest, leading to better survival.
Journal ArticleDOI
Production and characterisation of a novel chicken IgY antibody raised against C-terminal peptide from human thymidine kinase 1.
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