Sebastian Ullrich

TL;DR: This study provides an integrative portrait of the CLL epigenome, identifies extensive networks of altered regulatory elements and sheds light on the relationship between the genetic and epigenetic architecture of the disease.

TL;DR: Integration of chromatin modifications, methylation, and transcriptome dynamics reveals an enforced regulation of differentiation, for cellular functions such as release of proteases, respiratory burst, cell cycle regulation, and apoptosis, in neutrophils.

TL;DR: This work provides new insights into the role of IR during hematopoiesis, and on the main factors involved in regulating IR, by correlating the expression of non-core splicing factors with global IR levels, and analyzing RNA binding protein knockdown and eCLIP data.

TL;DR: A mathematical model consisting of a set of differential equations describing the time course of various ROS, components of the cellular antioxidant system, and a mitochondrial matrix protease involved in protein quality control is developed, demonstrating the role of superoxide as the primary ROS responsible for age-related molecular damage is more complicated than originally stated by the FRTA.

TL;DR: It is demonstrated that the usage of a second gRNA targeting the same gene synergistically enhances the capacity of the CRISPR-Cas9 system to knock out pc-genes and lncRNAs for genomic perturbation assays.