Journal ArticleDOI
Thymidine kinase and cancer monitoring
Stefan Aufderklamm,Tilman Todenhöfer,Georgios Gakis,Stephan Kruck,Joerg Hennenlotter,Arnulf Stenzl,Christian Schwentner +6 more
TLDR
The status of TK1 for cancer monitoring and its use as a proliferation marker are summarized and a comprehensive overview about the association of Tk-1 with various entities is given.About:
This article is published in Cancer Letters.The article was published on 2012-03-01. It has received 70 citations till now. The article focuses on the topics: Thymidine kinase 1 & Thymidine kinase.read more
Citations
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Journal ArticleDOI
Clinical significance and diagnostic capacity of serum TK1, CEA, CA 19-9 and CA 72-4 levels in gastric and colorectal cancer patients.
Ning Shufang,Wene Wei,Jilin Li,Bingbing Hou,Jian-Hong Zhong,Xie Yuxuan,Liu Haizhou,Xianwei Mo,Jiansi Chen,Litu Zhang +9 more
TL;DR: In conclusion, serum TK1 may be an independent tumor marker for GC and CRC patients, and the combination of TK 1, CA 19-9 and CA 72-4 and CEA performed even better.
Journal ArticleDOI
The proliferation marker thymidine kinase 1 in clinical use (Review)
TL;DR: Thymidine kinase 1 (TK1), a cell cycle-dependent and thus a proliferation-related marker, has been extensively studied during the last decades and is an emerging potential proliferating biomarker in oncology that may be used for the prognosis and monitoring of tumor therapy, relapse and survival.
Journal ArticleDOI
Serum thymidine kinase 1 activity as a pharmacodynamic marker of cyclin-dependent kinase 4/6 inhibition in patients with early-stage breast cancer receiving neoadjuvant palbociclib
Nusayba Bagegni,Shana Thomas,Ning Liu,Jingqin Luo,Jeremy Hoog,Donald W. Northfelt,Matthew P. Goetz,Andres Forero,Matthias Bergqvist,Jakob Karen,Magnus Neumuller,Edward M Suh,Zhanfang Guo,Kiran Vij,Souzan Sanati,Matthew J. Ellis,Cynthia X. Ma +16 more
TL;DR: Serum TK1 activity is a promising pharmacodynamic marker of palbociclib in ER+ breast cancer, and its value in predicting response to CDK4/6 inhibitors warrants further investigation.
Journal ArticleDOI
Crucial roles of thymidine kinase 1 and deoxyUTPase in incorporating the antineoplastic nucleosides trifluridine and 2'-deoxy-5-fluorouridine into DNA.
Kazuki Sakamoto,Tatsushi Yokogawa,Hiroyuki Ueno,Kei Oguchi,Hiromi Kazuno,Keiji Ishida,Nozomu Tanaka,Akiko Osada,Yukari Yamada,Hiroyuki Okabe,Kenichi Matsuo +10 more
TL;DR: The findings indicate that FTD and FdUrd are incorporated into DNA with different efficiencies due to differences in the substrate specificities of TK1 and DUT, causing abundant FTD incorporation into DNA.
Journal ArticleDOI
A review of HPRT and its emerging role in cancer.
TL;DR: Hypoxanthine guanine phosphoribosyltransferase has the potential to become a significant biomarker not only for the characterization of cancer, but also for its potential treatment.
References
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Journal ArticleDOI
The use of drug-resistant markers to study the hybridization of mouse fibroblasts.
TL;DR: When 2 clonal sublines of mouse fibroblasts lacking either guanylic acid-inosinic acid pyrophosphorylase or thymidine kinase were grown together in mixed culture for 4 days, it was possible by a selective technique to detect hybrid cells at a frequency of 1 to 5 × 10−6.
Journal ArticleDOI
Breast cancer (Third of three parts)
Journal ArticleDOI
Structural basis for substrate specificities of cellular deoxyribonucleoside kinases.
Kenth Johansson,S. Ramaswamy,S. Ramaswamy,Catarina Ljungcrantz,Wolfgang Knecht,Jure Piškur,Birgitte Munch-Petersen,S Eriksson,Hans Eklund +8 more
TL;DR: The structure of the Drosophila deoxyribonucleoside Kinase with deoxycytidine bound at the nucleoside binding site and that of the human deoxyguanosine kinase with ATP at the nucleus substrate binding site are reported.
Journal ArticleDOI
Mitotic Degradation of Human Thymidine Kinase 1 Is Dependent on the Anaphase-Promoting Complex/Cyclosome-Cdh1-Mediated Pathway
Po-Yuan Ke,Zee-Fen Chang +1 more
TL;DR: It is concluded that activation of the APC/C-Cdh1 complex during mitotic exit controls timing of hTK1 destruction, thus effectively minimizing dTTP formation from the salvage pathway in the early G1 phase of the cell cycle in mammalian cells.
Journal ArticleDOI
Structures of thymidine kinase 1 of human and mycoplasmic origin.
Martin Welin,U. Kosinska,Nils-Egil Mikkelsen,Cecilia Carnrot,Chunying Zhu,Liya Wang,Staffan Eriksson,Birgitte Munch-Petersen,Hans Eklund +8 more
TL;DR: The TK1 structure differs fundamentally from the structures of the other deoxyribonucleoside kinases, indicating a different evolutionary origin.