Journal ArticleDOI
The promise of minocycline in neurology
TLDR
The evidence for the efficacy of minocyCline in several animal models of neurological disease is described, the mechanisms by which minocycline affects a range of neurological diseases with diverse causes are discussed, and the emerging investigation of minocrycline in clinical neurology is introduced.Abstract:
Summary The capacity of minocycline to alleviate disease for several neurological disorders in animals is increasingly being recognised. Indeed, that one drug alone can attenuate the severity of disease in stroke, multiple sclerosis, spinal-cord injury, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis is astounding. In this review, we describe the evidence for the efficacy of minocycline in several animal models of neurological disease, discuss the mechanisms by which minocycline affects a range of neurological diseases with diverse causes, and introduce the emerging investigation of minocycline in clinical neurology. The encouraging results of minocycline in experimental neurology bode well for its therapeutic use in human neurological diseases.read more
Citations
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Minocycline: far beyond an antibiotic.
TL;DR: A review will cover the most important topics in the pharmacology of minocycline to date, supporting its evaluation as a new therapeutic approach for many of the diseases described herein.
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Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): The next decade
TL;DR: In Mmp9 gene knockout mice, specific spontaneous phenotypes emerged with effects on the skeletal, reproductive and nervous systems and stimulate research on the roles of MMPs and MMP-9 in endocrinology, immunology and the neurosciences.
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Activated Microglia Contribute to the Maintenance of Chronic Pain after Spinal Cord Injury
Bryan C. Hains,Stephen G. Waxman +1 more
TL;DR: An important role for activated microglia in the maintenance of chronic central below-level pain after SCI is suggested and the newly emerging role of non-neuronal immune cells as a contributing factor in post-SCI pain is supported.
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Metalloproteinases: Mediators of Pathology and Regeneration in the CNS
TL;DR: General principles that govern the expression of metalloproteinases in the nervous system are discussed and their mechanisms in regulating neurogenesis, myelin formation and axonal growth are focused on.
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Preclinical and clinical research on inflammation after intracerebral hemorrhage.
TL;DR: This review summarizes recent progress made in preclinical models of ICH, surveys preclinical and clinical studies of inflammatory cells (leukocytes, macrophages, microglia, and astrocytes) and inflammatory mediators and highlights the emerging areas of therapeutic promise.
References
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Journal ArticleDOI
Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease
Du Chu Wu,Vernice Jackson-Lewis,Miquel Vila,Kim Tieu,Peter Teismann,Caryn Vadseth,Dong-Kug Choi,Harry Ischiropoulos,Serge Przedborski +8 more
TL;DR: It is shown that minocycline, an approved tetracycline derivative that inhibits microglial activation independently of its antimicrobial properties, mitigates both the demise of nigrostriatal dopaminergic neurons and the formation of nitrotyrosine produced by MPTP.
Journal ArticleDOI
Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
Shan Zhu,Irina G. Stavrovskaya,Martin Drozda,Martin Drozda,Betty Y.S. Kim,Betty Y.S. Kim,Victor O. Ona,Victor O. Ona,Mingwei Li,Mingwei Li,Satinder Sarang,Allen S. Liu,Allen S. Liu,Dean M. Hartley,Du Chu Wu,Steven R. Gullans,Robert J. Ferrante,Robert J. Ferrante,Serge Przedborski,Serge Przedborski,Bruce S. Kristal,Robert M. Friedlander,Robert M. Friedlander +22 more
TL;DR: It is found that minocycline inhibits mitochondrial permeability-transition-mediated cytochrome c release, and this drug may be a novel therapy for ALS.
Journal ArticleDOI
Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease.
Minghua Chen,Victor O. Ona,Mingwei Li,Robert J. Ferrante,Klaus Fink,Shan Zhu,Jie Bian,Lei Guo,Laurie A. Farrell,Steve M. Hersch,Wendy Hobbs,Jean-Paul Vonsattel,Jang-Ho J. Cha,Robert M. Friedlander +13 more
TL;DR: It is reported that minocycline delays disease progression, inhibits casp enzyme-1 and caspase-3 mRNA upregulation, and decreases inducible nitric oxide synthetase activity, in the R6/2 mouse model of Huntington disease.
Journal ArticleDOI
A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window.
TL;DR: It is shown that daily treatment with minocycline reduces cortical infarction volume by 76 +/- 22% when the treatment is started 12 h before ischemia and by 63 +/- 35% when started even 4 h after the onset of ischemian, suggesting minocyCline may represent a prototype of an antiinflammatory compound that provides protection against ischemic stroke and has a clinically relevant therapeutic window.
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