Journal ArticleDOI
The redox couple between glutathione and ascorbic acid: a chemical and physiological perspective.
TLDR
The evidence for and the evidence against the presence of the enzyme dehydroascorbate reductase in animal cells is outlined in a balanced way in an attempt to make sense of this continuing controversy.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1994-10-01. It has received 484 citations till now. The article focuses on the topics: Ascorbic acid & Dehydroascorbic acid.read more
Citations
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Journal ArticleDOI
Metabolism and functions of glutathione in brain.
TL;DR: Recent results confirm the prominent role of astrocytes in glutathione metabolism and the defense against reactive oxygen species in brain and suggest an involvement of a compromised astroglial glutATHione system in the oxidative stress reported for neurological disorders.
Journal ArticleDOI
Physiology of astroglia
TL;DR: Astrocytes are tightly integrated into neural networks and act within the context of neural tissue; astrocytes control homeostasis of the CNS at all levels of organization from molecular to the whole organ.
Journal ArticleDOI
Reactive oxygen species and antioxidants: Relationships in green cells
TL;DR: Current data suggest that complex regulatory mechanisms function at both the gene and protein level to coordinate antioxidant responses and that a critical role is played by organellar localization and inter-compartment coordination.
Journal ArticleDOI
Ascorbic acid: Chemistry, biology and the treatment of cancer
TL;DR: It is shown that the chemical and biochemical nature of ascorbate contribute to its antioxidant as well as its prooxidant properties, and recent pharmacokinetic data indicate that intravenous (i.v.) administration of asCorbate bypasses the tight control of the gut producing highly elevated plasma levels.
Journal ArticleDOI
Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants
TL;DR: A deep understanding of the mechanisms involved in eliciting heavy metals toxicity is provided in order to highlight the necessity for development of strategies to decrease exposure to these metals, as well as to identify substances that contribute significantly to overcome their hazardous effects within the body of living organisms.
References
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Journal ArticleDOI
Oxidants, antioxidants, and the degenerative diseases of aging
TL;DR: It is argued that this damage to DNA, protein, and lipid is a major contributor to aging and to degenerative diseases of aging such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts.
Journal ArticleDOI
The biology of oxygen radicals
TL;DR: The reactive superoxide radical, O2-, formerly of concern only to radiation chemists and radiobiologists, is now understood to be a normal product of the biological reduction of molecular oxygen.
Journal ArticleDOI
The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate
TL;DR: In this article, the authors used one-electron reduction potentials to predict a pecking order, or hierarchy, for free radical reactions, which is in agreement with experimentally observed free radical electron (hydrogen atom) transfer reactions.
Book ChapterDOI
Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids
TL;DR: This chapter discusses selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids and suggests that prompt stabilization is especially important in the case of plasma or serum.
Journal ArticleDOI
Direct observation of a free radical interaction between vitamin E and vitamin C
TL;DR: Direct observation of the interaction between vitamin E and vitamin C and the resulting vitamin E radical then reacting with vitamin C to regenerate vitamin E is reported, which is felt to be an important feature in the maintenance of vitamin E levels in tissues.