Journal ArticleDOI
The role of lipid intermediates in the glycosylation of proteins in the eucaryotic cell.
Armando J. Parodi,Luis F. Leloir +1 more
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This article is published in Biochimica et Biophysica Acta.The article was published on 1979-04-23. It has received 346 citations till now. The article focuses on the topics: Glycosylation.read more
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Book ChapterDOI
Turns in peptides and proteins.
TL;DR: The aim of this chapter is to examine structural and functional roles of turns in peptides and proteins.
Book ChapterDOI
Cellular Biology and Biochemistry of the Retinoids
TL;DR: In this paper, the cellular biology and biochemistry of the retinoids are discussed and the effects of retinoid on cell differentiation in many different types of epithelia.
Book ChapterDOI
Primary structure of glycoprotein glycans: basis for the molecular biology of glycoproteins.
TL;DR: This chapter elaborates the primary structure and metabolism of the N -linked glycans, and presents the hypothesis that the catabolism of N -acetyl-lactosainine glycans starts by the action of endo-2-acetamido- 2-deoxy-β- D -glucosidases in liberating oligosaccharides that are then degraded by exoglycosidases.
Journal ArticleDOI
N-glycan structures: recognition and processing in the ER
TL;DR: Deciphering the "glyco-code of the ER" will be instrumental in understanding protein homeostasis regulation in eukaryotic cells and for intervention because such processes can have crucial importance for clinical and industrial applications.
Book ChapterDOI
Posttranslational enzymes in the biosynthesis of collagen: intracellular enzymes.
Kari I. Kivirikko,Raili Myllylä +1 more
TL;DR: This chapter describes the assay, purification, and properties of the enzymes catalyzing the unique intracellular modifications—i.e., the hydroxylases and hydroxylysyl glycosyltransferases.
References
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Journal ArticleDOI
Tunicamycin inhibition of polyisoprenyl N-acetylglucosaminyl pyrophosphate formation in calf-liver microsomes.
Jan S. Tkacz,J. Oliver Lampen +1 more
TL;DR: Tunicamycin inhibited the production of the [3H]G1cNAc-lipid but did not affect the synthesis of the 14C-mannolipid, which accounts for the effect of the antibiotic upon glycoprotein formation in vivo.
Journal ArticleDOI
Comparative Aspects of Glycoprotein Structure
TL;DR: Of all the biologically occurring macromolecules the glycoproteins, which consist of carbohydrate moieties convalently linked to a polypeptide backbone, represent the most diverse group, ranging from substances in which the carbohydrate component represents less than 1% of the total weight to those in which it represents over 80% ofThe total.
Journal ArticleDOI
The role of polyprenol-linked sugars in glycoprotein synthesis.
C J Waechter,W J Lennarz +1 more
TL;DR: The chiral stationary phase for lipid-Linked Monosaccharides showed good chiral recognition ability towards various lipids, and this property has been generalized to other lipids as well.
Journal ArticleDOI
Synchronised transmembrane insertion and glycosylation of a nascent membrane protein
TL;DR: A surprisingly precise sequence by which the nascent chain of this membrane glycoprotein is glycosylated in two steps is revealed, which has important implications for the mechanisms of membrane assembly.
Journal ArticleDOI
Proposal for a common oligosaccharide intermediate in the synthesis of membrane glycoproteins.
TL;DR: It is proposed that during glycosylation of asparagine residues, a common oligosaccharide is transferred from the lipid carrier to protein and is subsequently processed to yield the so-called "high mannose" and "complex" oligOSaccharides.