Journal ArticleDOI
The role of metabolism in 2-methoxyethanol-induced testicular toxicity.
Elizabeth J. Moss,Lucy V. Thomas,Melvyn W. Cook,David G. Walters,Paul M. D. Foster,Dianne M. Creasy,Tim J.B. Gray +6 more
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The results demonstrate that metabolic activation is required for 2-methoxyethanol to exert toxicity to the male reproductive system.About:
This article is published in Toxicology and Applied Pharmacology.The article was published on 1985-07-01. It has received 110 citations till now. The article focuses on the topics: Population & Toxicity.read more
Citations
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Journal ArticleDOI
Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse.
Kyoko Kitagawa,Toshihiro Kawamoto,Naoki Kunugita,Tadasuke Tsukiyama,Kohji Okamoto,Akira Yoshida,Keiko Nakayama,Keiichi I. Nakayama +7 more
TL;DR: In vitro MALD oxidation was examined with liver subcellular fractions from Japanese subjects who carried three different ALDH2 genotypes and Aldh2 knockout mice, which suggest that ALDH 2 is a key enzyme for Mald oxidation and ME susceptibility may be influenced by the AL DH2 genotype.
Book ChapterDOI
Sertoli Cell Toxicants
TL;DR: This chapter discusses toxicants that specifically target the Sertoli cell, which is the target of a testicular toxicant that may produce subtle alterations in germ cell function that trigger secondary manifestations of SERToli cell dysfunction as the earliest observed sign of testicular injury.
Journal ArticleDOI
Evidence that secretion of immunoactive inhibin by seminiferous tubules from the adult rat testis is regulated by specific germ cell types: correlation between in vivo and in vitro studies.
TL;DR: To confirm that the changes observed in vivo after MAA treatment were indicative of changes in Sertoli rather than Leydig cell secretion of immonoactive inhibin, its secretion by isolated ST was assessed, and a pattern of change similar to that in plasma was observed.
Journal ArticleDOI
Toxicokinetics of inhaled 2-butoxyethanol (ethylene glycol monobutyl ether) in man.
TL;DR: Seven male volunteers were exposed to 2-butoxyethanol at the Swedish occupational exposure limit (20 ppm or 0.85 mmol/m3) during light physical exercise on a bicycle ergometer during lightPhysical exercise (50 W) and a new sensitive method for analyzing 2- butoxy Ethanol in biological specimens is described.
Journal ArticleDOI
Toxicity review of ethylene glycol monomethyl ether and its acetate ester.
TL;DR: Ethylene glycol monomethyl ether and its acetate ester are highly flammable, colorless, moderately volatile liquids with very good solubility properties and should be considered as equally hazardous to man.
References
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Journal ArticleDOI
On the effects of some heterocyclic compounds on the enzymic activity of liver alcohol dehydrogenase.
H Theorell,T Yonetani,B Sjöberg +2 more
Journal Article
Mechanism of the inhibition of aldehyde dehydrogenase in vivo by disulfiram and diethyldithiocarbamate.
TL;DR: Results indicate that disulfiram is an irreversible inhibitor of aldehyde dehydrogenase in vivo and can be blocked by cycloheximide.
Journal ArticleDOI
Testicular toxicity of ethylene glycol monomethyl and monoethyl ethers in the rat.
Paul M. D. Foster,Dianne M. Creasy,John R. Foster,Lucy V. Thomas,Melvyn W. Cook,Sharat D. Gangolli +5 more
TL;DR: After dosing animals with 500 mg EGM/kg body weight for 4 days, the testes recovered weight, and the majority of tubules recovered their spermatogenic potential within one full maturation cycle.
Journal ArticleDOI
Comparative metabolism and disposition of ethylene glycol monomethyl ether and propylene glycol monomethyl ether in male rats
TL;DR: Differences in routes of metabolism and types of metabolites appear to be the underlying basis for the remarkably different toxicologic properties of EGME and PGME, respectively.
Journal ArticleDOI
Reproductive toxicity of the glycol ethers.
TL;DR: The glycol ethers are an important and widely used class of solvents and structure-activity relationships are speculated upon.