Journal ArticleDOI
The use of antikeratin antiserum as a diagnostic tool: thymoma versus lymphoma.
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TLDR
Indirect immunofluorescence staining of thymic tumors with antikeratin antibody provides a simple, specific, and sensitive method for distinguishing thymoma from lymphoma and seminoma and the method may also prove to be useful in other instances in the distinction between epithelial and nonepithelial tumors.About:
This article is published in Human Pathology.The article was published on 1980-11-01. It has received 136 citations till now. The article focuses on the topics: Thymoma.read more
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The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells
TL;DR: During cell transformation and tumor devel- opment this cell type specificity of intermediate filaments is largely conserved’ and classification of tumors by their specific type of intermediate Filaments has re- cently become very valuable in clinical histodiagnosis.
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Thymoma. A clinicopathologic review.
TL;DR: The clinical and pathologic features of 283 patients with thymoma treated at the Mayo Clinic were examined and poor prognostic factors included presence of tumor‐related symptoms, large tumor size, local invasion or metastasis in initial operation, and predominantly epithelial histologic features.
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Complex Cytokeratin Polypeptide Patterns Observed in Certain Human Carcinomas
TL;DR: Using cytoskeletal proteins from human biopsies and autopsies, the cytokeratin polypeptide patterns of diverse primary and metastatic carcinomas are examined and compared with those of corresponding normal epithelial tissues and cultured cells and the possibility of cell type heterogeneity within a given tumor is discussed.
Journal ArticleDOI
Antibodies to intermediate filament proteins in the immunohistochemical identification of human tumours: an overview.
Frans C. S. Ramaekers,J.J.G. Puts,O. Moesker,A. Kant,A. Huysmans,D. Haag,Paul H.K. Jap,C. J. Herman,G. P. Vooijs +8 more
TL;DR: Intermediate-sized filament proteins (IFP) are tissue specific in that antibodies to keratin, vimentin, desmin, glial fibrillary acidic protein (GFAP) and the neurofilament proteins can distinguish between cells of epithelial and mesenchymal origin as well as of myogenic and neural origin respectively.
Journal Article
Keratin immunoreactivity in the benign and neoplastic human prostate
TL;DR: The findings indicate that keratin immunoreactivity differs among the epithelial cell populations of the human prostate, probably reflecting expression of different keratin proteins.
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The unlabeled antibody enzyme method of immunohistochemistry preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes:
TL;DR: PAP was heterogeneous on electrophoresis, homogeneous on sedimentation, diffusion and electron microscopy and consisted of pentagons with diameters of 205 Å, with the unexpected ratio of PO to anti-PO presumed to be due to stabilization by the pentagonal shape.
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Different intermediate-sized filaments distinguished by immunofluorescence microscopy
TL;DR: Observations show that intermediate filaments with similar ultrastructure and solubility characteristics can be distinguished immunologically.
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Thymic hyperplasia and neoplasia: a review of current concepts.
Gerald D. Levine,Juan Rosai +1 more
TL;DR: Although the term thymic hyperplasia is used most commonly to indicate the occurrence of germinal centers in the thymus, cognizance must be taken of the fact that such centers may occur in apparently normal thymuses in both children and adults.
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Keratin cytoskeletons in epithelial cells of internal organs.
TL;DR: The results show that keratins constitute a cytoskeleton in epithelial cells of diverse morphology and embryological origin and the stability of keratin filaments probably confers the structural strength necessary for cells covering a free surface.
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Keratin filaments of cultured human epidermal cells. Formation of intermolecular disulfide bonds during terminal differentiation.
Tung-Tien Sun,Howard Green +1 more
TL;DR: The results indicate that the uncross-linked state of the keratins in living cells is due to the reducing intracellular environment and not to a precursor state related to the primary structure of the proteins.