The WHO policy package to combat antimicrobial resistance
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TLDR
To bring international attention to a growing public health threat, the World Health Organization (WHO) selected antimicrobial resistance as the theme for World Health Day 2011.Abstract:
To bring international attention to a growing public health threat, the World Health Organization (WHO) selected antimicrobial resistance as the theme for World Health Day 2011. Antimicrobial resistance is a threat to all branches of medical and public health practice. It challenges the control of infectious diseases, jeopardizes progress on health outcomes by increasing morbidity and mortality and imposes huge costs on societies. In the European Union, about 25000 patients die each year from infections caused by selected multidrug-resistant bacteria and the associated costs are estimated at about 1.5 billion euros per year.read more
Citations
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Success stories of implementation of antimicrobial stewardship: a narrative review
TL;DR: Although the best approach toeffective AMS remains elusive and may vary significantly among settings, these diverse examples from a range of healthcare contexts demonstrate that effective AMS is possible.
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Mary-Anne Ahiabu,Britt Pinkowski Tersbøl,Richard B. Biritwum,Ib C. Bygbjerg,Pascal Magnussen +4 more
TL;DR: The level of antibiotic use varied depending on the health facility type and was generally high compared with the national average estimated in 2008, and a diagnosis of upper respiratory tract infection was positively associated with antibiotic use.
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Protecting the tuberculosis drug pipeline: stating the case for the rational use of fluoroquinolones
Giovanni Battista Migliori,Miranda W. Langendam,Lia D'Ambrosio,Rosella Centis,Francesco Blasi,Emma Huitric,Davide Manissero,Marieke J. van der Werf +7 more
TL;DR: Although the majority of European countries hold national LRTI/CAP guidelines, the results suggest that a risk of developing FQ resistance exists, and further strengthening of, and adherence to, guidelines is needed to ensure rational use of FQs.
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Comparison of Sputum and Nasopharyngeal Aspirate Samples and of the PCR Gene Targets lytA and Spn9802 for Quantitative PCR for Rapid Detection of Pneumococcal Pneumonia
TL;DR: In CAP patients with good sputum production, this test has great potential to be used for the rapid detection of pneumococcal etiology and to target penicillin therapy.
References
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Journal ArticleDOI
Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study
Karthikeyan Kumarasamy,Mark Toleman,Timothy R. Walsh,Jay Bagaria,Fafhana Butt,Ravikumar Balakrishnan,Uma Chaudhary,Michel Doumith,Christian G. Giske,Seema Irfan,Padma Krishnan,Anil Kumar,Sunil Maharjan,Shazad Mushtaq,Tabassum Noorie,David L. Paterson,A. Pearson,Claire Perry,Rachel Pike,Bhargavi Rao,Ujjwayini Ray,Jayanta B. Sarma,Madhu Sharma,Elizabeth Sheridan,M A Thirunarayan,Jane F. Turton,Supriya Upadhyay,Marina Warner,William Welfare,David M. Livermore,Neil Woodford +30 more
TL;DR: The prevalence of NDM-1, in multidrug-resistant Enterobacteriaceae in India, Pakistan, and the UK is investigated, and co-ordinated international surveillance is needed.
Journal ArticleDOI
Trends in Antimicrobial Drug Development: Implications for the Future
TL;DR: The need for new antimicrobial agents is greater than ever because of the emergence of multidrug resistance in common pathogens, the rapid emergence of new infections, and the potential for use of multi-drug-resistant agents in bioweapons.
Journal ArticleDOI
The Bacteria Fight Back
TL;DR: In their ongoing war against antibiotics, the bacteria seem to be winning, and the drug pipeline is verging on empty.
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Hospital and societal costs of antimicrobial-resistant infections in a Chicago teaching hospital: implications for antibiotic stewardship.
Rebecca R. Roberts,Bala Hota,Bala Hota,I. Ahmad,R. Douglas Scott,Susan Foster,Fauzia Abbasi,Shari Schabowski,Linda M. Kampe,Ginevra G. Ciavarella,Mark Supino,Jeremy Naples,Ralph L. Cordell,Stuart B. Levy,Robert A. Weinstein,Robert A. Weinstein +15 more
TL;DR: Data from this analysis could form the basis for a more comprehensive evaluation of the cost of resistance and the potential economic benefits of prevention programs.
Journal ArticleDOI
The epidemiology of antimicrobial resistance in hospital acquired infections: problems and possible solutions
TL;DR: In this paper, a review of the current problems caused by major drug resistant nosocomial pathogens, examine factors that promote antibiotic resistance in hospitals, and discuss strategies for control, including strategies for controlling antibiotic resistant bacteria in hospitals.
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