The WHO policy package to combat antimicrobial resistance
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TLDR
To bring international attention to a growing public health threat, the World Health Organization (WHO) selected antimicrobial resistance as the theme for World Health Day 2011.Abstract:
To bring international attention to a growing public health threat, the World Health Organization (WHO) selected antimicrobial resistance as the theme for World Health Day 2011. Antimicrobial resistance is a threat to all branches of medical and public health practice. It challenges the control of infectious diseases, jeopardizes progress on health outcomes by increasing morbidity and mortality and imposes huge costs on societies. In the European Union, about 25000 patients die each year from infections caused by selected multidrug-resistant bacteria and the associated costs are estimated at about 1.5 billion euros per year.read more
Citations
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Dimeric unnatural polyproline-rich peptides with enhanced antibacterial activity
TL;DR: Continuous dimerization of an unnatural proline-rich peptide was a successful strategy to create potent de novo antibacterial peptides without membrane lysis.
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Bioactivity and antibacterial activity against E-coli of calcium-phosphate-based glasses: Effect of silver content and crystallinity
M.N. Capela,David M. Tobaldi,Carlos Augusto Fernandes de Oliveira,Anabela Pereira,Ana Sofia Duarte,Maria Paula Seabra,Maria Helena Fernandes +6 more
TL;DR: In this paper, a melt-quenched bioactive glass of the SiO 2 -CaO-P 2 O 5 -MgO system was modified with the addition of 1 and 2 mol% Ag 2 O and the 1 ǫmol% ag 2 O-containing glasses were then heat treated to produce glass-ceramics.
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Phenotypic and Molecular Epidemiology of Acinetobacter calcoaceticus baumannii Complex Strains Spread at Nemazee Hospital of Shiraz, Iran
Mojtaba Anvarinejad,Aziz Japoni,Mohammad Ali Davarpanah,Hossein Mahmudi,Caterina Mammina,Afsaneh Vazin +5 more
TL;DR: High resistance to antibiotics was observed among the strains of ACB complex and the least resistance was towards colistin and polymyxin B, indicating that these antibiotics could be effective for treatment, in case there is no other choice.
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Educating in antimicrobial resistance awareness: adaptation of the Small World Initiative program to service-learning.
María José Valderrama,Bruno Gonzalez-Zorn,Pilar Calvo de Pablo,Rosalía Diez-Orejas,Teresa Fernández-Acero,Jéssica Gil-Serna,Lucía de Juan,Humberto Martín,María Molina,Federico Navarro-García,Belén Patiño,Jesús Pla,Daniel Prieto,Carmina Rodríguez,Elvira Román,Ana Belén Sanz-Santamaría,Maria Isabel de Silóniz,Mónica Suárez,Covadonga Vázquez,Víctor J. Cid +19 more
TL;DR: The Small World Initiative (SWI) and Tiny Earth are a consolidated and successful education programs rooted in the USA that tackle the antibiotic crisis by a crowdsourcing strategy that involves two education levels (higher education and high school) with different degrees of responsibility.
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Antimicrobial resistance dynamics and the one-health strategy: a review
Kumar Siddharth Singh,Santosh Anand,Sunny Dholpuria,Jitendra Kumar Sharma,Wulf Blankenfeldt,Yogesh S. Shouche +5 more
TL;DR: In this article, the authors discuss the historical issue of using antibiotics and present strategies for mitigation of antimicrobial resistance, exemplified by the successful ban of triclosan which induced a significant decline of resistant pathogens.
References
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Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study
Karthikeyan Kumarasamy,Mark Toleman,Timothy R. Walsh,Jay Bagaria,Fafhana Butt,Ravikumar Balakrishnan,Uma Chaudhary,Michel Doumith,Christian G. Giske,Seema Irfan,Padma Krishnan,Anil Kumar,Sunil Maharjan,Shazad Mushtaq,Tabassum Noorie,David L. Paterson,A. Pearson,Claire Perry,Rachel Pike,Bhargavi Rao,Ujjwayini Ray,Jayanta B. Sarma,Madhu Sharma,Elizabeth Sheridan,M A Thirunarayan,Jane F. Turton,Supriya Upadhyay,Marina Warner,William Welfare,David M. Livermore,Neil Woodford +30 more
TL;DR: The prevalence of NDM-1, in multidrug-resistant Enterobacteriaceae in India, Pakistan, and the UK is investigated, and co-ordinated international surveillance is needed.
Journal ArticleDOI
Trends in Antimicrobial Drug Development: Implications for the Future
TL;DR: The need for new antimicrobial agents is greater than ever because of the emergence of multidrug resistance in common pathogens, the rapid emergence of new infections, and the potential for use of multi-drug-resistant agents in bioweapons.
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The Bacteria Fight Back
TL;DR: In their ongoing war against antibiotics, the bacteria seem to be winning, and the drug pipeline is verging on empty.
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Hospital and societal costs of antimicrobial-resistant infections in a Chicago teaching hospital: implications for antibiotic stewardship.
Rebecca R. Roberts,Bala Hota,Bala Hota,I. Ahmad,R. Douglas Scott,Susan Foster,Fauzia Abbasi,Shari Schabowski,Linda M. Kampe,Ginevra G. Ciavarella,Mark Supino,Jeremy Naples,Ralph L. Cordell,Stuart B. Levy,Robert A. Weinstein,Robert A. Weinstein +15 more
TL;DR: Data from this analysis could form the basis for a more comprehensive evaluation of the cost of resistance and the potential economic benefits of prevention programs.
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The epidemiology of antimicrobial resistance in hospital acquired infections: problems and possible solutions
TL;DR: In this paper, a review of the current problems caused by major drug resistant nosocomial pathogens, examine factors that promote antibiotic resistance in hospitals, and discuss strategies for control, including strategies for controlling antibiotic resistant bacteria in hospitals.
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