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Open AccessJournal ArticleDOI

The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity

TLDR
Developing countries, especially those in Africa and southern Asia, incur the highest burden in terms of absolute numbers, although a high rate is also observed in North America.
Abstract
Resumen Incidencia mundial de parto prematuro: revision sistematica de la morbilidad y mortalidad maternas Objetivo Analizar las tasas de prematuridad a nivel mundial para evaluar la incidencia de este problema de salud publica, determinar la distribucion regional de los partos prematuros y profundizar en el conocimiento de las actuales estrategias de evaluacion.Metodos Los datos utilizados sobre las tasas de prematuridad a nivel mundial se extrajeron a lo largo de una revision sistematica anterior de datos publicados e ineditos sobre la mortalidad y morbilidad maternas notificados entre 1997 y 2002. Esos datos se complementaron mediante una busqueda que abarco el periodo 2003–2007. Las tasas de prematuridad de los paises sin datos se estimaron mediante modelos de regresion multiple especificos para cada region.Resultados Estimamos que en 2005 se registraron 12,9 millones de partos prematuros, lo que representa el 9,6% de todos los nacimientos a nivel mundial. Aproximadamente 11 millones (85%) de ellos se concentraron en Africa y Asia, mientras que en Europa y America del Norte (excluido Mexico) se registraron 0,5 millones en cada caso, y en America Latina y el Caribe, 0,9 millones. Las tasas mas elevadas de prematuridad se dieron en Africa y America del Norte (11,9% y 10,6% de todos los nacimientos, respectivamente), y las mas bajas en Europa (6,2%).Conclusion El parto prematuro es un problema de salud perinatal importante en todo el mundo. Los paises en desarrollo, especialmente de Africa y Asia meridional, son los que sufren la carga mas alta en terminos absolutos, pero en America del Norte tambien se observa una tasa elevada. Es necesario comprender mejor las causas de la prematuridad y obtener estimaciones mas precisas de la incidencia de ese problema en cada pais si se desea mejorar el acceso a una atencion obstetrica y neonatal eficaz.

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Journal ArticleDOI

Perinatal Brain Injury As a Consequence of Preterm Birth and Intrauterine Inflammation: Designing Targeted Stem Cell Therapies.

TL;DR: The injurious cascade of events in the preterm brain in response to a severe fetal inflammatory event is described and specific periods of increased vulnerability are highlighted, and the potential effects of therapeutic intervention with cell-based therapies are highlighted.
Journal ArticleDOI

Long-term impact of preterm birth on exercise capacity in healthy young men: a national population-based cohort study.

TL;DR: Being born preterm as well as being born small for gestational age predicts low exercise capacity in otherwise healthy young men, which may equal or exceed that of other known risk factors for unfitness in adults, such as low parental education and overweight.
Journal ArticleDOI

Why the United States preterm birth rate is declining.

TL;DR: A large portion of preterm births in the United States could still be prevented with greater access and implementation of current interventions, the reduction of modifiable risk factors for preterm birth, and expanded reporting of outcomes and risk factors to facilitate research for both prevention and treatment.
Journal ArticleDOI

Role of Maternal Periodontitis in Preterm Birth

TL;DR: This article reviews recent epidemiological, animal, and in vitro studies as well as intervention trials that evaluate the link between periodontitis and PTB and proposed new ideas are proposed here: (1) severe and/or generalizedperiodontitis promotesPTB and (2) Periodontitis only promotes PTB for pregnant women who are young or HIV-infected or have preeclampsia, pre-pregnancy obesity, or susceptible genotypes.
Journal ArticleDOI

The short-term prediction of preterm birth: a systematic review and diagnostic metaanalysis

TL;DR: In this paper, the diagnostic accuracy of fetal fibronectin (fFN), fetal breathing movements (FBM), and cervical length (CL) for the short-term prediction of preterm birth in symptomatic patients was assessed.
References
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Book

Applied Regression Analysis

TL;DR: In this article, the Straight Line Case is used to fit a straight line by least squares, and the Durbin-Watson Test is used for checking the straight line fit.
Journal ArticleDOI

Epidemiology and causes of preterm birth

TL;DR: A short cervical length and a raised cervical-vaginal fetal fibronectin concentration are the strongest predictors of spontaneous preterm birth.
Journal ArticleDOI

The preterm parturition syndrome

TL;DR: The evidence indicating that the pathological processes implicated in the preterm parturition syndrome include: intrauterine infection/inflammation; uterine ischaemia; (3) uterine overdistension; (4) abnormal allograft reaction; (5) allergy; (6) cervical insufficiency; and (7) hormonal disorders (progesterone related and corticotrophin‐releasing factor related).
Journal ArticleDOI

Epidemiology of preterm birth

TL;DR: Over the past 20-30 years advances in perinatal care have improved outcomes for infants born after short gestations, but there is still uncertainty and incomplete recording of estimates of gestation in developed countries.
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