Journal ArticleDOI
The zinc/thiolate redox biochemistry of metallothionein and the control of zinc ion fluctuations in cell signaling.
TLDR
At the center of zinc/redox signaling are the zinc/thiolate clusters of metallothionein, which can transduce zinc and redox signals and thereby attenuate or amplify these signals.About:
This article is published in Archives of Biochemistry and Biophysics.The article was published on 2007-07-15. It has received 231 citations till now. The article focuses on the topics: Zinc & Metallothionein.read more
Citations
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Journal ArticleDOI
Zinc Biochemistry: From a Single Zinc Enzyme to a Key Element of Life
TL;DR: It is fair to conclude that the impact of zinc for health and disease will be at least as far-reaching as that of iron.
Journal ArticleDOI
Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression
Richard C. Shelton,J Claiborne,M Sidoryk-Wegrzynowicz,Rakesh Reddy,Michael Aschner,David A. Lewis,Karoly Mirnics +6 more
TL;DR: The results of this study indicate that post-mortem brain tissue samples from BA10, a region that is involved in reward-related behavior, show evidence of local inflammatory, apoptotic, and oxidative stress in MDD.
Journal ArticleDOI
Zinc as a Gatekeeper of Immune Function
TL;DR: Molecular mechanisms underlying the development of a pro-inflammatory phenotype during zinc deficiency are reported, and links between altered zinc homeostasis and disease development are described, ensuring the benefits of zinc supplementation for a malfunctioning immune system become clear.
Journal ArticleDOI
Cytosolic zinc buffering and muffling: Their role in intracellular zinc homeostasis
TL;DR: It is suggested that the biological functions of transient changes in cytosolic zinc ion concentrations (presumptive zinc signals) complement those of calcium ions in both spatial and temporal dimensions.
References
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Journal ArticleDOI
The biochemical basis of zinc physiology
TL;DR: Majors topics addressed in this review on zinc physiology are chemistry and biochemistry; interface of biochemistry and physiology of zinc; physiology and cell and molecular biology; and pathology.
Journal ArticleDOI
Oxidized redox state of glutathione in the endoplasmic reticulum
TL;DR: Results suggest that the demonstrated preferential transport of GSSG compared to GSH into the ER lumen may contribute to this redox compartmentation.
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The neurobiology of zinc in health and disease
TL;DR: The use of zinc in medicinal skin cream was mentioned in Egyptian papyri from 2000 BC, and the number of biological functions, health implications and pharmacological targets that are emerging for zinc indicate that it might turn out to be 'the calcium of the twenty-first century'.
Journal ArticleDOI
Femtomolar Sensitivity of Metalloregulatory Proteins Controlling Zinc Homeostasis
TL;DR: The mechanism of zinc sensors that control metal uptake or export in Escherichia coli are determined and their response against the thermodynamically defined free zinc concentration suggests an extraordinary intracellular zinc-binding capacity.
Journal ArticleDOI
A cadmium protein from equine kidney cortex
Marvin Margoshes,Bert L. Vallee +1 more
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