Journal ArticleDOI
Thymic stromal lymphopoietin is expressed and produced by caspase-1/NF-κB pathway in mast cells.
Phil-Dong Moon,Hyung-Min Kim +1 more
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TLDR
Results provide proof of principle that TSLP can be expressed and produced through caspase-1 and NF-κB in mast cells and open new perspectives to pharmacologically manipulate the expression and production of T SLP by molecules acting on the casp enzyme and NF -κB pathway.About:
This article is published in Cytokine.The article was published on 2011-06-01. It has received 106 citations till now. The article focuses on the topics: Thymic stromal lymphopoietin.read more
Citations
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Journal ArticleDOI
TSLP expression: cellular sources, triggers, and regulatory mechanisms.
TL;DR: This review focuses on events upstream of TSLP production, which is critical in allergic diseases and important in other T SLP-related disorders i.e. production sites, cellular sources, environmental and endogenous triggers and regulatory factors, and regulatory mechanisms of gene expression.
Journal ArticleDOI
Cytokine inhibition in the treatment of COPD
TL;DR: There is a need to carefully phenotype COPD and discover good biomarkers of drug efficacy for each specific target, and specific groups of COPD patients should be targeted with specific anticytokine therapy if there is evidence of high expression of that cytokine and there are features of the clinical expression of COPd that will respond.
Journal ArticleDOI
Mast cell activation: A complex interplay of positive and negative signaling pathways
TL;DR: This review presents the latest understanding of FcεRI and FcγR signaling, required for the canonical mast cell activation during allergic responses and anaphylaxis and reports how the FcR activation could be used as a therapeutic approach to treat allergic and atopic diseases by mast cell inactivation.
Journal ArticleDOI
MicroRNA-375 Regulation of Thymic Stromal Lymphopoietin by Diesel Exhaust Particles and Ambient Particulate Matter in Human Bronchial Epithelial Cells
Bertram Bleck,Gabriele Grunig,Amanda Chiu,Mengling Liu,Terry Gordon,Angeliki Kazeros,Joan Reibman +6 more
TL;DR: It is shown that two pollutants, DEP and ambient PM, upregulate TSLP in human bronchial epithelial cells by a mechanism that includes hsa-miR-375 with complex regulatory effects on AhR mRNA.
Journal ArticleDOI
Cellular and Molecular Mechanisms of TSLP Function in Human Allergic Disorders - TSLP Programs the “Th2 code” in Dendritic Cells
TL;DR: Thymic stromal lymphopoietin (TSLP) has been recently implicated as a key molecule for initiating allergic inflammation at the epithelial cell-dendritic cell (DC) interface and is a rational therapeutic target for the treatment of allergic disorders.
References
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Journal ArticleDOI
Mast cells as a source of multifunctional cytokines
TL;DR: It is suggested that the production of a broad panel of multifunctional cytokines may represent an important mechanism by which mast cells influence physiological, immunological and pathological processes.
Journal ArticleDOI
Thymic stromal lymphopoietin: master switch for allergic inflammation
TL;DR: New reports now establish a direct link between TSLP expression and the pathogenesis of atopic dermatitis and asthma in vivo, and begin to reveal the molecular mechanisms underlying T SLP-induced allergic inflammation.
Journal Article
A thymic stromal cell line supports in vitro development of surface IgM+ B cells and produces a novel growth factor affecting B and T lineage cells
TL;DR: A thymic stromal cell line with a medullary phenotype that supported the differentiation of surface IgM+ B cells when cocultured with fetal liver cells in vitro exhibits a functional homology to bone marrow or fetal liverStromal cells not previously appreciated.
Journal ArticleDOI
Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFκB
TL;DR: It is found that both IL-1β and TNF-α were capable of inducing rapid TSLP production in primary human bronchial airway epithelial cells and analysis of the mouse T SLP gene promoter revealed the presence of a similarly situated NFκB site that was also critical for IL- 1β-inducible expression of mouse TSlP.
Journal ArticleDOI
Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation.
Hilmar Quentmeier,Hans G. Drexler,Diana S. Fleckenstein,Margarete Zaborski,Armstrong A,Sims Je,Stewart D. Lyman +6 more
TL;DR: The cloning and characterization of the human homologue of murine TSLP is described and its proliferative effects on a myeloid cell line MUTZ-3 are described.
Related Papers (5)
Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP
Vassili Soumelis,Pedro A. Reche,Holger Kanzler,Wei Yuan,Gina Edward,Bernhart Homey,Michel Gilliet,Steve Ho,Svetlana Antonenko,Annti Lauerma,Kathleen M. Smith,Daniel M. Gorman,Sandra Zurawski,Jon Abrams,Satish Menon,Terri McClanahan,Rene de Waal-Malefyt,Fernando Bazan,Robert A. Kastelein,Yong-Jun Liu +19 more