Journal ArticleDOI
Thyroid disorders in chronic hepatitis C virus infection
Alessandro Antonelli,Clodoveo Ferri,Poupak Fallahi,Silvia Martina Ferrari,Alessandra Ghinoi,Mario Rotondi,Ele Ferrannini +6 more
TLDR
A significant increase of the prevalence has been observed both for thyroid autoimmune disorders as well as for hypothyroidism, and the abovementioned evidences seem sufficient to suggest careful thyroid monitoring during the follow-up of patients with HCV infection.Abstract:
The prevalence of thyroid disorders has been evaluated in patients with hepatitis C virus (HCV) infection by many studies. From a review of the published controlled studies, it is possible to observe that: (1) most investigated patients with chronic HCV hepatitis, while a minority evaluated hepatitis C virus antibody (HCVAb)- seropositive patients (the two conditions are not comparable with regards to thyroidal repercussions, in fact, HCVAb-seropositive patients do not necessarily display changes of the immune system present in chronically infected HCV patients); and (2) some authors selected as internal control hepatitis B virus (HBV)-infected patients, while others selected apparently healthy controls or HCVAb-negative subjects. Pooling all data about HCV-positive patients (with chronic hepatitis or HCVAb positivity) and using as control the sum of healthy controls, HBV-infected patients and sera negative for HCVAb, a significant increase of the prevalence has been observed both for thyroid autoimmune d...read more
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Journal ArticleDOI
Autoimmune thyroid disorders.
Alessandro Antonelli,Silvia Martina Ferrari,Alda Corrado,Andrea Di Domenicantonio,Poupak Fallahi +4 more
TL;DR: E Epidemiological data suggest that AITD patients should be accurately monitored for thyroid dysfunctions, the appearance of thyroid nodules, and other autoimmune disorders.
Journal ArticleDOI
Viruses and thyroiditis: an update
Rachel Desailloud,Didier Hober +1 more
TL;DR: This review examines the data related to the role of viruses in the development of thyroiditis at different levels of evidence; epidemiological data, serological data or research on circulating viruses, direct evidence of thyroid tissue infection.
Journal ArticleDOI
The etiology of autoimmune thyroid disease: a story of genes and environment.
Yaron Tomer,Amanda K. Huber +1 more
TL;DR: Recent data on the genetic predisposition to AITD lead to novel putative mechanisms by which the genetic-environmental interactions may lead to the development of thyroid autoimmunity.
Journal ArticleDOI
[Prophylaxis, diagnosis and therapy of hepatitis C virus (HCV) infection: the German guidelines on the management of HCV infection].
Christoph Sarrazin,Thomas Berg,R. S. Ross,Peter Schirmacher,H. Wedemeyer,Ulf P. Neumann,Hartmut Schmidt,Ulrich Spengler,Stefan Wirth,Harald H. Kessler,Markus Peck-Radosavljevic,P. Ferenci,Wolfgang Vogel,Darius Moradpour,Markus H. Heim,Markus Cornberg,Ulrike Protzer,M.P. Manns,Wolfgang E. Fleig,Matthias M. Dollinger,Stefan Zeuzem +20 more
TL;DR: Eine internationale Leitlinie with Gultigkeit im gesamten deutschen Sprachraum geschaffen werden, durch die zusatzliche Teilnahme der Osterreichischen Gesellschaft fur Gastroenterologie
Journal ArticleDOI
Endocrine and liver interaction: the role of endocrine pathways in NASH
TL;DR: Clinicians should be aware of the potential role of endocrine disorders in patients with cryptogenic liver disease and of the effects of liver function on the endocrine system, as evidence that causally links hormonal disorders with hepatobiliary disease is reviewed.
References
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TL;DR: A random-primed complementary DNA library was constructed from plasma containing the uncharacterized non-A, non-B hepatitis agent and screened with serum from a patient diagnosed with NANBH, showing consistent with the agent being similar to the togaviridae or flaviviridae.
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TL;DR: The strongest factors independently associated with HCV infection were illegal drug use and high-risk sexual behavior, and poverty, having had 12 or fewer years of education, and having been divorced or separated were independently associated.
Journal ArticleDOI
Binding of Hepatitis C Virus to CD81
Piero Pileri,Yasushi Uematsu,Susanna Campagnoli,Giuliano Galli,Fabiana Falugi,Roberto Petracca,Amy J. Weiner,Michael Houghton,Domenico Rosa,Guido Grandi,Sergio Abrignani +10 more
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Journal ArticleDOI
An overview of the immune system.
Jacqueline Parkin,Bryony Cohen +1 more
TL;DR: In this review, the normal function of the immune system in recognising, repelling, and eradicating pathogens and other foreign molecules is covered.
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Prevalence of Type 2 Diabetes Mellitus among Persons with Hepatitis C Virus Infection in the United States
Shruti H. Mehta,Frederick Brancati,Mark S. Sulkowski,Steffanie A. Strathdee,Moyses Szklo,David L. Thomas +5 more
TL;DR: The hypothesis that persons with HCV infection have an increased prevalence of type 2 diabetes after adjustment for important confounding variables, including age, body mass index, poverty level, and history of drug and alcohol use is tested.